What is the distance between Florence and Pittsburgh?

About 431 miles (695 km) separate Florence and Pittsburgh.

What are the departure and arrival stations when taking the bus from Florence to Pittsburgh?

If you're headed to Pittsburgh from Florence, chances are that your bus will leave from Florence Bus Station and arrive at Intermodal Station. These are the main departure and arrival locations on this route, but you can also find other options that could better fit your plans.

Bus Florence to Pittsburgh from $81 | Refundable Tickets

Previously seen trips

Next departures for Florence to Pittsburgh on November 21
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound + FlixBus	Bus	11:59pm	Florence, SC	23h 56m	11:55pm	Pittsburgh Intermodal Station	No tags
	Bus	4:15pm	Bus station	20h 30m	12:45pm	Pittsburgh Intermodal Station	No tags
	Bus	4:15pm	Bus station	20h 30m	12:45pm	Pittsburgh Intermodal Station	No tags
Greyhound + FlixBus	Bus	11:59pm	Florence, SC	23h 56m	11:55pm	Pittsburgh Intermodal Station	No tags
	Bus	4:15pm	Bus station	20h 30m	12:45pm	Pittsburgh Intermodal Station	No tags

Compare 2 ways to go from Florence to Pittsburgh

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach Pittsburgh. The journey takes about 17 hours 45 minutes and with fares starting at just $86, it presents an excellent value for a comfortable ride.

1bus per day

17h 45mAverage Duration

432 milesDistance

17kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$86 - $379	Average Duration17h 45m	CO₂ emissions 17kg CO₂e
Train	Average Price$199 - $402	Average Duration1d	CO₂ emissions 63kg CO₂e

Where are the popular stops in Florence and Pittsburgh?

Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Stops in Pittsburgh

A
Intermodal Station
55 11th St, Pittsburgh, PA 15222, USA
Visit page
B
Sennott Square
201 S Bouquet St, Pittsburgh, PA 15213, USA

Compare bus companies

FlixBus

3.5/511,388 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

Greyhound

3.5/587,386 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about traveling from Florence, SC, US to Pittsburgh by bus

What is the distance between Florence and Pittsburgh?
What are the departure and arrival stations when taking the bus from Florence to Pittsburgh?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/18

No data

11/19

No data

Today

No data

11/21

$137

11/22

No data

11/23

No data

11/24

No data

11/25

$127

The cheapest trip from Florence, SC, US to Pittsburgh was searched and found on Nov 25, 2025 with a price of $127

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Pittsburgh, as early as possible.

You can expect to pay from $127 to $137 for a bus ticket from Florence, SC, US to Pittsburgh based on the last 2 days. You can expect to find the cheapest price for the trip at $127 which is on 2025-11-25.