Bus Tickets from Florence, SC, US to Pittsburgh

Previously seen trips

Next departures for Florence to Pittsburgh on November 21
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound + FlixBus
Bus
Florence, SC
Pittsburgh Intermodal StationNo tags
GreyhoundBus
Bus station
Pittsburgh Intermodal StationNo tags
GreyhoundBus
Bus station
Pittsburgh Intermodal StationNo tags
Greyhound + FlixBus
Bus
Florence, SC
Pittsburgh Intermodal StationNo tags
GreyhoundBus
Bus station
Pittsburgh Intermodal StationNo tags

Compare 2 ways to go from Florence to Pittsburgh

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach Pittsburgh. The journey takes about 17 hours 45 minutes and with fares starting at just $86, it presents an excellent value for a comfortable ride.

1bus per day
17h 45mAverage Duration
432 milesDistance
17kgCO₂ emissions
Average Price$86 - $379Average Duration17h 45m
17kg CO₂e
Average Price$199 - $402Average Duration1d
63kg CO₂e

Frequently asked questions about traveling from Florence, SC, US to Pittsburgh by bus

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
11/18
No data
11/19
No data
Today
No data
11/21
$137
11/22
No data
11/23
No data
11/24
No data
11/25
$127
busbud logoThe cheapest trip from Florence, SC, US to Pittsburgh was searched and found on Nov 25, 2025 with a price of $127

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Pittsburgh, as early as possible.

You can expect to pay from $127 to $137 for a bus ticket from Florence, SC, US to Pittsburgh based on the last 2 days. You can expect to find the cheapest price for the trip at $127 which is on 2025-11-25.

What's the cheapest way to go from Florence, SC, US to Pittsburgh?

busbud logoThe bus is the cheapest travel choice for this destination

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