Bus Tickets from Knoxville, TN to Gainesville, FL

Find affordable bus tickets from Knoxville, TN to Gainesville, FL with flexible options. Book your trip now

Join 75M+ travelers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every step.
Cancel anytime and receive a 100% refund, no reason needed.
TodayJul 29
TomorrowJul 30
ThuJul 31
FriAug 1
from $100
SatAug 2
SunAug 3
from $80
MonAug 4
TueAug 5

Cheap buses leaving Friday

One passenger / one way

  • This trip is recommended because it is: Cheapest + Fastest
    Departure time: August 1 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: August 2 at
    Destination city: Gainesville
    Destination location: Gainesville Bus Stop
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 1 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: August 2 at
    Destination city: Gainesville
    Destination location: Rosa Parks Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Knoxville, TN to Gainesville, FL: Trip Overview

Average ticket price$116
Average bus trip duration11h
Number of daily buses2
Earliest bus departure7:25pm
Distance443 miles (713 km)

Knoxville to Gainesville Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Knoxville to Gainesville.

Bus service from Knoxville to Gainesville will be provided by the most trusted bus companies.

Whether it is cheap bus tickets or more luxurious buses going to Gainesville from Knoxville, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Knoxville, TN - Gainesville, FL

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
07/27
$73
07/28
$72
Today
No data
07/30
$72
07/31
No data
08/01
$92
08/02
No data
08/03
$73
busbud logoThe cheapest trip from Knoxville, TN to Gainesville, FL was searched and found on Jul 28, 2025 with a price of $72

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Gainesville, FL, as early as possible.

You can expect to pay from $72 to $92 for a bus ticket from Knoxville, TN to Gainesville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at $72 which is on 2025-07-30.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Knoxville to Gainesville but it'll also be endearing to native speakers who will surely appreciate your effort.

Much more than a mere vehicle taking you from Knoxville to Gainesville, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Knoxville to Gainesville.

Tune out to the fine sounds of your best music playlist on your bus trip from Knoxville to Gainesville while indulging in miles on end of beautiful scenic views.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Will you be returning to Knoxville, TN by bus?

Bus from Knoxville, TN to Gainesville, FL

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌