Next departures for Rochester to San Diego on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Greyhound + FlixBus
Bus
Rochester
UCSD Health La Jolla Station
No tags
Greyhound + FlixBus
Bus
Rochester
Downtown SD (Seaport)
No tags
Bus
Rochester
Greyhound Bus Stop
No tags
FlixBus + Greyhound
Bus
Rochester
5716 Hardy Ave
No tags
Greyhound + FlixBus
Bus
Rochester
Balboa Park
No tags
Compare 2 ways to go from Rochester to San Diego
We recommend taking the train
Among the sustainable travel choices, the train stands out as the good way to reach San Diego. The journey takes about 2 days, 16 hours 24 minutes and with fares starting at just $324, it presents an excellent value for a comfortable ride.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Rochester, NY, US to San Diego, CA, US by bus
What is the travel distance from Rochester to San Diego?
Rochester and San Diego are 2246 miles (3623 km) apart.
What are the departure and arrival stations when taking the bus from Rochester to San Diego?
The majority of buses traveling from Rochester to San Diego start their journey at Bus Station and wind up at Mission Valley Sheraton. These are the most popular departure and arrival locations on this route, but you could find others that could be a better fit for your travel plans.
What are the best sights and things to do in San Diego?
Once in San Diego, you can start exploring the city and discover its surroundings. The top sights and things to do are Sunset Cliffs Natural Park, La Jolla Cove, The Gaslamp Quarter, Botanical Building and Lily Pond and Boat Tours in San Diego.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/22
No data
11/23
$533
Today
No data
11/25
No data
11/26
No data
11/27
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11/28
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11/29
No data
The cheapest trip from Rochester, NY, US to San Diego, CA, US was searched and found on Nov 23, 2025 with a price of $533
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rochester, NY, US to San Diego, CA, US, as early as possible.
What's the cheapest way to go from Rochester, NY, US to San Diego, CA, US?
The bus is the cheapest travel choice for this destination