Next departures for San Antonio to San Diego on November 23
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Valley Transit + FlixBus + Greyhound
Bus
San Antonio Bus Station
Downtown SD (Seaport)
No tags
Valley Transit + Greyhound + FlixBus
Bus
San Antonio Bus Station
Balboa Park
No tags
Valley Transit + Greyhound
Bus
San Antonio Bus Station
Greyhound Bus Stop
No tags
Greyhound + Valley Transit + FlixBus
Bus
San Antonio Bus Station
UCSD Health La Jolla Station
No tags
FlixBus + Greyhound
Bus
San Antonio Bus Station
San Diego (Old Town-FlixBus)
No tags
Compare 2 ways to go from San Antonio to San Diego
We recommend taking the train
Among the sustainable travel choices, the train stands out as the good way to reach San Diego. The journey takes about 1 day, 9 hours 19 minutes and with fares starting at just $167, it presents an excellent value for a comfortable ride.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Based on 33 reviews, the company was rated 3 stars on Busbud. Travelers were especially satisfied with the departure location and the staff but often complained with the wifi. Valley Transit ticket prices on this trip start at $98
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from San Antonio, US to San Diego, CA, US by bus
How far is San Antonio from San Diego?
About 1125 miles (1815 km) separate San Antonio and San Diego.
What are the departure and arrival stations when taking the bus from San Antonio to San Diego?
Most of the buses traveling from San Antonio to San Diego leave from San Antonio Bus Station and arrive at Mission Valley Sheraton. These are the main pick-up and drop-off locations on this route, but you can also find other options that could better fit your plans.
What are the best sights and things to do in San Diego?
Once in San Diego, you can start exploring the city and discover its surroundings. The top sights and things to do are Torrey Pines Gliderport, Old Town, The Gaslamp Quarter, Cabrillo National Monument and SeaWorld San Diego.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/21
$150
11/22
$406
Today
$114
11/24
No data
11/25
No data
11/26
No data
11/27
$142
11/28
No data
The cheapest trip from San Antonio, US to San Diego, CA, US was searched and found on Nov 23, 2025 with a price of $114
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Antonio, US to San Diego, CA, US, as early as possible.
You can expect to pay from $114 to $406 for a bus ticket from San Antonio, US to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $142 which is on 2025-11-27.
What's the cheapest way to go from San Antonio, US to San Diego, CA, US?
The bus is the cheapest travel choice for this destination