Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | The Florida Mall | Cheapest | ||||
 | Bus | Tupelo (Brothers Quick Stop) | Orlando Bus Station | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Orlando Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | The Florida Mall | No tags |
Last refresh of the prices: Today at 2:28 AM CST.
Get from Tupelo to Orlando
The journey takes about 17 hours 55 minutes and with fares starting at just $108, it presents an excellent value for a comfortable ride.
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Lines, Inc. Tupelo Orlando recent customer reviews
The only problem I had was one of the buses bathroom door will not stay shut and I was seated right next to it and it stunk horribly
Paul H.
Frequently asked questions about traveling from Tupelo to Orlando by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Tupelo to Orlando?
The cheapest bus tickets from Tupelo to Orlando start from $108. The average price for this route is around $166. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Tupelo to Orlando?
The average bus trip duration from Tupelo to Orlando is 17h 55m, covering a distance of 586 miles (945 km). The quickest bus can get you there in 16h 5m and is operated by Greyhound.
Which bus companies service the Tupelo to Orlando route?
Several major train operators operate on this route with 4 trains available per day.
What is the earliest and latest departure time for the bus from Tupelo to Orlando?
The earliest bus departs from Tupelo to Orlando at 10:55am. And the latest bus departs at 11:15pm.
What are the CO₂ emissions for the bus trip from Tupelo to Orlando?
A bus trip from Tupelo to Orlando generates an estimated 24 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tupelo to Orlando was searched and found on Dec 21, 2025 with a price of $188To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to Orlando, as early as possible.
You can expect to pay from $188 to $188 for a bus ticket from Tupelo to Orlando based on the last 2 days. You can expect to find the cheapest price for the trip at $188 which is on 2025-12-21.
