Bus Tickets from Durham, NC, US to Louisville

Previously seen trips

Next departures for Durham to Louisville on November 1
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus
    		Durham Greyhound Bus Station
    		Louisville, KYNo tags
    FlixBus + Greyhound
      		Durham Greyhound Bus Station
      		Louisville, KYNo tags
      Greyhound + FlixBus
        		Durham Greyhound Bus Station
        		Louisville, KYNo tags
        FlixBus + Greyhound
          		Durham Greyhound Bus Station
          		Louisville, KYNo tags
          Greyhound
            		Durham Greyhound Bus Station
            		Louisville, KYNo tags

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            Get from Durham to Louisville

            This route is served by bus only

            The journey takes about 18 hours 25 minutes, and with fares starting at just US$105, it presents an excellent value for a comfortable ride.

            5bus per day
            18h 25mAverage Duration
            659 kmDistance
            16kgCO₂ emissions

            Bus Durham, NC, US to Louisville: Trip Overview

            Average Ticket PriceUS$157
            Average Bus Trip Duration18h 25m
            Number of daily buses5
            Earliest bus departure1:10am
            Distance658 km
            Latest bus departure10:05pm

            Durham to Louisville Bus

            With Busbud, comparing and booking tickets for a bus from Durham to Louisville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

            We make sure you can find a bus service from Durham to Louisville from the most reliable bus companies operating this trip.

            From cheap bus tickets to more luxurious buses travelling from Durham to Louisville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

            Frequently asked questions on the trip Durham, NC, US - Louisville

            1. What is the travel distance from Durham to Louisville?

              It's about 659 km (409 miles) from Durham to Louisville.

            2. What are the departure and arrival locations for buses traveling from Durham to Louisville?

              Buses traveling this route start their trip at Durham Greyhound Bus Station, in Durham, and end it at Louisville Greyhound Bus Station, in Louisville.

            Find cheapest prices for buses

            Price is for a one-way ticket for one passenger and based on past searches.

            Best price found
            10-29
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            US$118
            11-01
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            busbud logoThe cheapest trip from Durham, NC, US to Louisville was searched and found on Oct 31, 2025 with a price of US$118

            To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Durham, NC, US to Louisville, as early as possible.

            About Bus Travel

            Bus Travel Tips

            Meet and talk to locals at the bus stations while travelling from Durham to Louisville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

            Start sightseeing the minute your bus leaves the station. If you're on the night bus from Durham to Louisville, get comfy and count the stars.

            Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Durham to Louisville that are otherwise impossible to come by with a plane.

            Tune out to the fine sounds of your best music playlist on your bus trip from Durham to Louisville while indulging in miles on end of beautiful scenic views.

            Did you know?

            The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

            It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

            The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

            Will you be returning to Durham, NC, US by bus?

            Bus from Louisville to Durham, NC, US

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