How do I get from Gainesville to Knoxville without flying?

The best way to travel from Gainesville to Knoxville is by bus. Traveling by bus offers a budget-friendly, secure, and easy way to go between the two cities. Taking a ride with other travelers through carpool services is an additional option to consider.

How long is the bus ride from Gainesville to Knoxville?

The travel time from Gainesville to Knoxville is about 21h 30m, although the minimum time it takes to get there is 14h 5m with the fastest bus. This is the time it takes to travel the 446 miles (718 km) that separate the two cities.

How far is Gainesville from Knoxville?

The distance between the two cities is 446 miles (718 km).

What are the departure and arrival stations when taking the bus from Gainesville to Knoxville?

Most of the buses traveling from Gainesville to Knoxville leave from Rosa Parks Station and arrive at 100 Kirkwood St. These are the main departure and arrival locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.

What is the cheapest way to get from Gainesville to Knoxville?

You can save a lot of money on your trip from Gainesville to Knoxville by choosing to travel by bus. With prices starting at $93, you won't find a more affordable way to get there.

How much does a bus ticket from Gainesville to Knoxville cost?

The average bus ticket price from Gainesville to Knoxville is $109. Over the last 30 days, the prices ranged between $93 and $191, so make sure to compare them to get the best option.

Gainesville (FL) to Knoxville (TN) Bus Tickets

TodayMay 14

TomorrowMay 15

from $104

FriMay 16

SatMay 17

SunMay 18

MonMay 19

TueMay 20

WedMay 21

Cheap buses leaving tomorrow

One passenger / one way

This trip is recommended because it is: Cheapest
Departure time: May 15 at 1:10am
Departure city: Gainesville
Departure location: Rosa Parks Station
Arrival time: May 15 at 10:25pm
Destination city: Knoxville
Destination location: Knoxville Bus Station
Operated by: FlixBus + Greyhound Lines, Inc.
FlixBus + Greyhound Lines, Inc.
Vehicle: BusDuration: 21h 15m
This trip is recommended because it is: Fastest
Departure time: May 15 at 8:00am
Departure city: Gainesville
Departure location: Gainesville Bus Stop
Arrival time: May 15 at 10:05pm
Destination city: Knoxville
Destination location: Knoxville Bus Station
Operated by: Greyhound Lines, Inc.
Vehicle: BusDuration: 14h 5m
Departure time: May 15 at 8:00am
Departure city: Gainesville
Departure location: Gainesville Bus Stop
Arrival time: May 15 at 10:05pm
Destination city: Knoxville
Destination location: Knoxville Bus Station
Operated by: Greyhound Lines, Inc.
Vehicle: BusDuration: 14h 5m
Departure time: May 15 at 10:40pm
Departure city: Gainesville
Departure location: Rosa Parks Station
Arrival time: May 16 at 10:05pm
Destination city: Knoxville
Destination location: Knoxville Bus Station
Operated by: FlixBus + Greyhound Lines, Inc.
FlixBus + Greyhound Lines, Inc.
Vehicle: BusDuration: 23h 25m

Accepted payments

Bus Gainesville to Knoxville: Trip Overview

Average ticket price$109

Average bus trip duration21h 30m

Number of daily buses3

Earliest bus departure1:10am

Distance448 miles (721 km)

Latest bus departure10:40pm

Compare bus companies

Greyhound

3.5/586,978 reviews

Staff3.6

Timeliness2.8

Cleanliness3.3

Wifi2.3

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

Greyhound Lines, Inc. Gainesville Knoxville recent customer reviews

So I had a family emergency that didn't allow me to make the trip and greyhound didn't do anything for me when trying to reschedule my ticket ... Super upset and I lost the money for the ticket as well as the trip I think I was treated unfairly

Nathan S.

November 17, 2024

FlixBus

3.5/58,614 reviews

Staff4.1

Timeliness4

Cleanliness4.1

Wifi2.6

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

US bus companies: FlixBus, Greyhound, Los Limousines, Tornado Bus, Valley Transit, Tufesa, Wanda Coach

Gainesville to Knoxville Bus

With Busbud, comparing and booking tickets for a bus from Gainesville to Knoxville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Gainesville to Knoxville.

Discover how much the bus trip from Gainesville to Knoxville will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Where are the popular stops in Gainesville and Knoxville?

Stops in Gainesville

A - Rosa Parks Station

B - Williston Rd & I-75

C - Greyhound Station

Stops in Knoxville

A - 100 Kirkwood St

Frequently asked questions for your trip Gainesville - Knoxville

How do I get from Gainesville to Knoxville without flying?
How long is the bus ride from Gainesville to Knoxville?
How far is Gainesville from Knoxville?
What are the departure and arrival stations when taking the bus from Gainesville to Knoxville?
What is the cheapest way to get from Gainesville to Knoxville?
How much does a bus ticket from Gainesville to Knoxville cost?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

05/12

$147

05/13

$85

Today

$97

05/15

$131

05/16

$105

05/17

No data

05/18

$96

05/19

No data

The cheapest trip from Gainesville to Knoxville was searched and found on May 13, 2025 with a price of $85

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Gainesville to Knoxville, as early as possible.

You can expect to pay from $85 to $147 for a bus ticket from Gainesville to Knoxville based on the last 2 days. You can expect to find the cheapest price for the trip at $96 which is on 2025-05-18.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Gainesville to Knoxville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Gainesville to Knoxville.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Gainesville to Knoxville will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Gainesville to Knoxville.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to Gainesville by bus?

Bus from Gainesville to Knoxville

Top traveled bus routes

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

Bus Tickets from Gainesville, FL to Knoxville, TN