Bus Tickets from Gainesville, FL to Knoxville, TN

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TodayJul 27
TomorrowJul 28
TueJul 29
WedJul 30
ThuJul 31
FriAug 1
from $109
SatAug 2
from $104
SunAug 3

Cheap buses leaving Friday

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: August 1 at
    Departure city: Gainesville
    Departure location: Rosa Parks Station
    Arrival time: August 1 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: August 1 at
    Departure city: Gainesville
    Departure location: Gainesville Bus Stop
    Arrival time: August 1 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 1 at
    Departure city: Gainesville
    Departure location: Gainesville Bus Stop
    Arrival time: August 1 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 1 at
    Departure city: Gainesville
    Departure location: Rosa Parks Station
    Arrival time: August 2 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Bus Gainesville, FL to Knoxville, TN: Trip Overview

Average ticket price$128
Average bus trip duration21h 30m
Number of daily buses2
Earliest bus departure1:10am
Distance448 miles (721 km)
Latest bus departure10:40pm

Gainesville to Knoxville Bus

With Busbud, comparing and booking tickets for a bus from Gainesville to Knoxville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Gainesville to Knoxville.

Discover how much the bus trip from Gainesville to Knoxville will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip Gainesville, FL - Knoxville, TN

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
07/25
No data
07/26
No data
Today
$133
07/28
No data
07/29
No data
07/30
No data
07/31
No data
08/01
$113
busbud logoThe cheapest trip from Gainesville, FL to Knoxville, TN was searched and found on Aug 1, 2025 with a price of $113

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Gainesville, FL to Knoxville, TN, as early as possible.

You can expect to pay from $113 to $133 for a bus ticket from Gainesville, FL to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at $113 which is on 2025-08-01.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Gainesville to Knoxville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Gainesville to Knoxville.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Gainesville to Knoxville will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Gainesville to Knoxville.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to Gainesville, FL by bus?

Bus from Gainesville, FL to Knoxville, TN

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Popular bus departures from Gainesville

Popular bus departures to Gainesville

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