Next departures for Houston to San Diego on November 22
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Houston Uptown/Upper Kirby
San Diego (Old Town-FlixBus)
Cheapest
Bus
Houston Bus Station
Greyhound Bus Stop
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
Houston Bus Station
San Diego (Old Town-FlixBus)
No tags
Bus
Houston Bus Station
Greyhound Bus Stop
No tags
Valley Transit + Greyhound Lines, Inc. + FlixBus
Bus
Hillcroft Ave & Southwest Freeway
San Diego (Old Town-FlixBus)
No tags
Next departures for Houston to San Diego on November 23
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Greyhound Lines, Inc. + FlixBus
Bus
Houston Bus Station
UCSD Health La Jolla Station
Cheapest
Bus
Houston Bus Station
Greyhound Bus Stop
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
Houston Bus Station
San Diego (Old Town-FlixBus)
No tags
Bus
Houston Bus Station
Greyhound Bus Stop
No tags
Valley Transit + Greyhound Lines, Inc. + FlixBus
Bus
Hillcroft Ave & Southwest Freeway
UCSD Health La Jolla Station
No tags
Next departures for Houston to San Diego on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Greyhound Lines, Inc. + FlixBus
Bus
Houston Bus Station
UCSD Health La Jolla Station
Cheapest
Bus
Houston Bus Station
Greyhound Bus Stop
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
Houston Bus Station
San Diego (Old Town-FlixBus)
No tags
Bus
Houston Bus Station
Greyhound Bus Stop
No tags
Valley Transit + Greyhound Lines, Inc. + FlixBus
Bus
Hillcroft Ave & Southwest Freeway
UCSD Health La Jolla Station
No tags
Next departures for Houston to San Diego on November 25
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Houston Bus Station
Greyhound Bus Stop
Cheapest
Greyhound Lines, Inc. + FlixBus
Bus
Houston Bus Station
UCSD Health La Jolla Station
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
Houston Bus Station
San Diego (Old Town-FlixBus)
No tags
Bus
Houston Bus Station
Greyhound Bus Stop
No tags
Valley Transit + Greyhound Lines, Inc. + FlixBus
Bus
Hillcroft Ave & Southwest Freeway
San Diego (Old Town-FlixBus)
No tags
Last refresh of the prices: Last Wednesday at 2:46 PM CST.
Compare 2 ways to go from Houston to San Diego
We recommend taking the train
Among the sustainable travel choices, the train stands out as the good way to reach San Diego. The journey takes about 1 day, 16 hours 55 minutes and with fares starting at just $202, it presents an excellent value for a comfortable ride.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Houston San Diego recent customer reviews
Two connections were very late but the drivers made up the time. One driver was very nasty and rude but other than that it was okay
4 out of 5 stars
Edward W.
I appreciated all the help from Iris at the Houston Station She was amazing, changed all my trip to the better! Thanks!!
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Based on 33 reviews, the company was rated 3 stars on Busbud. Travelers were especially satisfied with the departure location and the staff but often complained with the wifi. Valley Transit ticket prices on this trip start at $118
Frequently asked questions about traveling from Houston, US to San Diego, CA, US by bus
What is the travel distance from Houston to San Diego?
The distance separating Houston and San Diego is 1300 miles (2097 km).
What are the departure and arrival stations when taking the bus from Houston to San Diego?
The majority of buses traveling from Houston to San Diego start their journey at Hillcroft Ave & Southwest Freeway and wind up at Mission Valley Sheraton. These are the main departure and arrival locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.
What are the best sights and things to do in San Diego?
Once in San Diego, you can start exploring the city and discover its surroundings. The top sights and things to do are Boat Tours in San Diego, Cabrillo National Monument, Old Point Loma Lighthouse, San Diego Bay Waterfront and Pacific Surf School.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/19
$234
11/20
$310
Today
$166
11/22
$185
11/23
$150
11/24
$165
11/25
$195
11/26
$170
The cheapest trip from Houston, US to San Diego, CA, US was searched and found on Nov 23, 2025 with a price of $150
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Houston, US to San Diego, CA, US, as early as possible.
You can expect to pay from $150 to $389 for a bus ticket from Houston, US to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $150 which is on 2025-11-23.
What's the cheapest way to go from Houston, US to San Diego, CA, US?
The bus is the cheapest travel choice for this destination
The cheapest trip from Houston, US to San Diego, CA, US was searched and found on Nov 23, 2025 with a price of $150
The bus is the cheapest travel choice for this destination
