How much is the bus ticket from Mexicali to Santa Ana?

The cheapest bus tickets from Mexicali to Santa Ana start from $54. The average price for this route is around $54. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Mexicali to Santa Ana?

The average bus trip duration from Mexicali to Santa Ana is 7h 10m, covering a distance of 294 miles (473 km). The quickest bus can get you there in 5h 30m and is operated by Interbus de Sinaloa .

Which bus companies service the Mexicali to Santa Ana route?

Several major bus companies operate on this route with 30 buses available per day, including services from Tufesa , Chihuahuenses , Interbus de Sinaloa , Aguacaliente , Futura .

What is the earliest and latest departure time for the bus from Mexicali to Santa Ana?

The earliest bus departs from Mexicali to Santa Ana at 12:20am. And the latest bus departs at 11:59pm.

What are the CO₂ emissions for the bus trip from Mexicali to Santa Ana?

A bus trip from Mexicali to Santa Ana generates an estimated 12 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

What is the best bus company from Mexicali to Santa Ana?

According to Busbud customers, the highest-rated bus company on this route is Interbus de Sinaloa , with an average rating of 4.0 out of 5 stars based on 4 reviews.

Which bus company has the best Wi-Fi from Mexicali to Santa Ana?

Based on reviews on Busbud, the bus company Tufesa has the best Wi-Fi rating with a score of 3.0.

Which bus company has the most timely service from Mexicali to Santa Ana?

According to Busbud traveller reviews, the most timely bus company on this route is Interbus de Sinaloa , with a punctuality rating of 3.4 out of 5 stars.

Which bus company has the cleanest buses from Mexicali to Santa Ana?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Tufesa , with a cleanliness rating of 4.1 out of 5 stars.

Bus Mexicali to Santa Ana from $54 | Refundable Tickets

Next bus departures

Next departures for Mexicali to Santa Ana on January 11
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	3:50pm	Mexicali Central Bus Station, Avenida Francisco Sarabia 1298, Mexicali	7h 10m	12:00am	Santa Ana	Cheapest
Bus	4:00pm	Mexicali - Stop	6h 30m	11:30pm	Santa Ana (Paso) - Stop	Fastest
Bus	8:00pm	Mexicali - Stop	6h 30m	3:30am	Santa Ana (Paso) - Stop	No tags
Bus	3:30pm	Tufesa	6h 50m	11:20pm	Santa Ana Col Del Rio	No tags
Bus	4:05pm	Mexicali Central Bus Station, Avenida Francisco Sarabia 1298, Mexicali	7h 10m	12:15am	Santa Ana	No tags

Next departures for Mexicali to Santa Ana on January 12
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	12:20am	Mexicali Central Bus Station, Avenida Francisco Sarabia 1298, Mexicali	6h 25m	7:45am	Santa Ana	Cheapest
Bus	1:15pm	Mexicali Central Bus Station, Avenida Francisco Sarabia 1298, Mexicali	6h 10m	8:25pm	Santa Ana	Fastest
Bus	4:00pm	Mexicali - Stop	6h 30m	11:30pm	Santa Ana (Paso) - Stop	No tags
Bus	9:00am	Tufesa	7h	5:00pm	Santa Ana Col Del Rio	No tags
Bus	1:15am	Mexicali Central Bus Station, Avenida Francisco Sarabia 1298, Mexicali	7h 10m	9:25am	Santa Ana	No tags

Next departures for Mexicali to Santa Ana on January 13
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	12:20am	Mexicali Central Bus Station, Avenida Francisco Sarabia 1298, Mexicali	6h 25m	7:45am	Santa Ana	Cheapest
Bus	1:15pm	Mexicali Central Bus Station, Avenida Francisco Sarabia 1298, Mexicali	6h 10m	8:25pm	Santa Ana	Fastest
Bus	4:00pm	Mexicali - Stop	6h 30m	11:30pm	Santa Ana (Paso) - Stop	No tags
Bus	9:00am	Tufesa	7h	5:00pm	Santa Ana Col Del Rio	No tags
Bus	1:15am	Mexicali Central Bus Station, Avenida Francisco Sarabia 1298, Mexicali	7h 10m	9:25am	Santa Ana	No tags

Next departures for Mexicali to Santa Ana on January 14
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	12:20am	Mexicali Central Bus Station, Avenida Francisco Sarabia 1298, Mexicali	6h 25m	7:45am	Santa Ana	Cheapest
Bus	1:15pm	Mexicali Central Bus Station, Avenida Francisco Sarabia 1298, Mexicali	6h 10m	8:25pm	Santa Ana	Fastest
Bus	4:00pm	Mexicali - Stop	6h 30m	11:30pm	Santa Ana (Paso) - Stop	No tags
Bus	1:00pm	Tufesa	6h 50m	8:50pm	Santa Ana Col Del Rio	No tags
Bus	1:15am	Mexicali Central Bus Station, Avenida Francisco Sarabia 1298, Mexicali	7h 10m	9:25am	Santa Ana	No tags

Next departures for Mexicali to Santa Ana on January 15
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	12:20am	Mexicali Central Bus Station, Avenida Francisco Sarabia 1298, Mexicali	6h 25m	7:45am	Santa Ana	Cheapest
Bus	1:15pm	Mexicali Central Bus Station, Avenida Francisco Sarabia 1298, Mexicali	6h 10m	8:25pm	Santa Ana	Fastest
Bus	4:00pm	Mexicali - Stop	6h 30m	11:30pm	Santa Ana (Paso) - Stop	No tags
Bus	1:00pm	Tufesa	6h 50m	8:50pm	Santa Ana Col Del Rio	No tags
Bus	1:15am	Mexicali Central Bus Station, Avenida Francisco Sarabia 1298, Mexicali	7h 10m	9:25am	Santa Ana	No tags

Next departures for Mexicali to Santa Ana on January 16
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	12:20am	Mexicali Central Bus Station, Avenida Francisco Sarabia 1298, Mexicali	6h 25m	7:45am	Santa Ana	Cheapest
Bus	1:15pm	Mexicali Central Bus Station, Avenida Francisco Sarabia 1298, Mexicali	6h 10m	8:25pm	Santa Ana	Fastest
Bus	4:00pm	Mexicali - Stop	6h 30m	11:30pm	Santa Ana (Paso) - Stop	No tags
Bus	9:00am	Tufesa	7h	5:00pm	Santa Ana Col Del Rio	No tags
Bus	1:15am	Mexicali Central Bus Station, Avenida Francisco Sarabia 1298, Mexicali	7h 10m	9:25am	Santa Ana	No tags

Next departures for Mexicali to Santa Ana on January 18
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	12:20am	Mexicali Central Bus Station, Avenida Francisco Sarabia 1298, Mexicali	6h 25m	7:45am	Santa Ana	Cheapest
Bus	1:15pm	Mexicali Central Bus Station, Avenida Francisco Sarabia 1298, Mexicali	6h 10m	8:25pm	Santa Ana	Fastest
Bus	4:00pm	Mexicali - Stop	6h 30m	11:30pm	Santa Ana (Paso) - Stop	No tags
Bus	9:00am	Tufesa	7h	5:00pm	Santa Ana Col Del Rio	No tags
Bus	1:15am	Mexicali Central Bus Station, Avenida Francisco Sarabia 1298, Mexicali	7h 10m	9:25am	Santa Ana	No tags

Last refresh of the prices: Last Thursday at 12:03 PM PST.

Compare 2 ways to go from Mexicali to Santa Ana

We recommend carpooling

Among the sustainable travel choices, the Carpool stands out as the good way to reach Santa Ana. The journey takes about 7 hours 20 minutes and with fares starting at just $26, it presents an excellent value for a comfortable ride.

1carpool per day

7h 20mAverage Duration

293 milesDistance

20kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$54 - $71	Average Duration7h 10m	CO₂ emissions 12kg CO₂e
Carpool	Average Price$26 - $28	Average Duration7h 20m	CO₂ emissions 20kg CO₂e

Where are the popular stops in Mexicali and Santa Ana?

Stops in Mexicali

A
Terminal de Autobuses de Mexicali
Calzada Independencia No. 1244 (entre Blvd. Anahuac y Lopez Mateos, Col. Centro Civico), 21000 Mexicali
Visit page Map
B
Nuevo Mexicali
Blvd. Lázaro Cárdenas 2666 -1 , Fraccionamiento, Col. Nuevo Mexicali
Map
C
Restaurant El Mexicano
México 2, Puebla, 21620 Puebla, B.C., Mexico
Visit page Map
D
Apozol Central 27
Apozol Central 27, Zacatecas, Mexicali, B.C., Mexico
Map
E
Bvld Lázaro Cárdenas
Blvrd Lázaro Cárdenas #3295, Mexicali, B.C., Mexico
Map

Stops in Santa Ana

A
Parada de Autobuses de Santa Ana
Avenida Aldama # 301 entre Cerna y Guerrero - Colonia Centro, 84600 Santa Ana
Visit page Map

Compare bus companies

Tufesa

3.5/5706 reviews

Staff4.2

Timeliness2.7

Cleanliness4.1

Wifi3

Since 1994, Tufesa has been offering comfortable, safe, and affordable bus travel in the United States (California, Nevada, Utah, Arizona and Texas) and Mexico (Baja California Sur, Sonora, Sinaloa and Guadalajara). Tufesa buses are equipped with comfortable reclining seats, power outlets, bathrooms, and WiFi (only in Mexico). Tickets are non-refundable, but you can exchange them up to 1 hour before travel time for a small fee. The company accepts e-tickets, so you don't have to worry about printing your boarding pass. With over 8 daily trips, you'll surely find a convenient trip that fits your needs and your schedule.

Chihuahuenses

3/5166 reviews

Staff4

Timeliness2.7

Cleanliness3.5

Wifi1.8

Interbus de Sinaloa

4/54 reviews

Staff1.7

Timeliness3.4

Cleanliness3.4

Wifi2.5

Aguacaliente

Futura

3.5/5755 reviews

Staff4

Timeliness2.7

Cleanliness3.8

Wifi1.7

MX bus companies:FlixBus, BlaBlaCar Bus, Greyhound, ALSA, Intercape, Trenitalia, Big Sky

Frequently asked questions about traveling from Mexicali to Santa Ana, SON, MX by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Mexicali to Santa Ana?
The cheapest bus tickets from Mexicali to Santa Ana start from $54. The average price for this route is around $54. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Mexicali to Santa Ana?
The average bus trip duration from Mexicali to Santa Ana is 7h 10m, covering a distance of 294 miles (473 km). The quickest bus can get you there in 5h 30m and is operated by Interbus de Sinaloa.
Which bus companies service the Mexicali to Santa Ana route?
Several major bus companies operate on this route with 30 buses available per day, including services from Tufesa, Chihuahuenses, Interbus de Sinaloa, Aguacaliente, Futura.
What is the earliest and latest departure time for the bus from Mexicali to Santa Ana?
The earliest bus departs from Mexicali to Santa Ana at 12:20am. And the latest bus departs at 11:59pm.
What are the CO₂ emissions for the bus trip from Mexicali to Santa Ana?
A bus trip from Mexicali to Santa Ana generates an estimated 12 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Mexicali to Santa Ana?
According to Busbud customers, the highest-rated bus company on this route is Interbus de Sinaloa, with an average rating of 4.0 out of 5 stars based on 4 reviews.
Which bus company has the best Wi-Fi from Mexicali to Santa Ana?
Based on reviews on Busbud, the bus company Tufesa has the best Wi-Fi rating with a score of 3.0.
Which bus company has the most timely service from Mexicali to Santa Ana?
According to Busbud traveller reviews, the most timely bus company on this route is Interbus de Sinaloa, with a punctuality rating of 3.4 out of 5 stars.
Which bus company has the cleanest buses from Mexicali to Santa Ana?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Tufesa, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

01/09

$54

01/10

$54

Today

$54

01/12

$54

01/13

$54

01/14

$54

01/15

$54

01/16

$54

The cheapest trip from Mexicali to Santa Ana, SON, MX was searched and found on Jan 12, 2026 with a price of $54

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Mexicali to Santa Ana, SON, MX, as early as possible.

You can expect to pay from $54 to $64 for a bus ticket from Mexicali to Santa Ana, SON, MX based on the last 2 days. You can expect to find the cheapest price for the trip at $54 which is on 2026-01-12.

Usually Tufesa will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.