Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Mexicali Central Bus Station, Avenida Francisco Sarabia 1298, Mexicali | Santa Ana | Cheapest | ||||
 | Bus | Mexicali Central Bus Station, Avenida Francisco Sarabia 1298, Mexicali | Santa Ana | Fastest | ||||
 | Bus | Mexicali - Stop | Santa Ana (Paso) - Stop | No tags | ||||
 | Bus | Tufesa | Santa Ana Col Del Rio | No tags | ||||
 | Bus | Mexicali Central Bus Station, Avenida Francisco Sarabia 1298, Mexicali | Santa Ana | No tags |
Last refresh of the prices: Last Sunday at 7:56 AM PST.
Compare 2 ways to go from Mexicali to Santa Ana
Among the sustainable travel choices, the Carpool stands out as the good way to reach Santa Ana. The journey takes about 7 hours 20 minutes and with fares starting at just $26, it presents an excellent value for a comfortable ride.
| Average Price | Average Duration | CO₂ emissions | Actions | |
|---|---|---|---|---|
| Average Price$54 - $71 | Average Duration7h 10m | 12kg CO₂e | ||
Carpool | Average Price$26 - $28 | Average Duration7h 20m | 20kg CO₂e |
Where are the popular stops in Mexicali and Santa Ana?
Stops in Mexicali
- A
Terminal de Autobuses de Mexicali
Calzada Independencia No. 1244 (entre Blvd. Anahuac y Lopez Mateos, Col. Centro Civico), 21000 Mexicali - B
Nuevo Mexicali
Blvd. Lázaro Cárdenas 2666 -1 , Fraccionamiento, Col. Nuevo Mexicali - CMéxico 2, Puebla, 21620 Puebla, B.C., Mexico
- D
Apozol Central 27
Apozol Central 27, Zacatecas, Mexicali, B.C., Mexico - E
Bvld Lázaro Cárdenas
Blvrd Lázaro Cárdenas #3295, Mexicali, B.C., Mexico
Stops in Santa Ana
- A
Parada de Autobuses de Santa Ana
Avenida Aldama # 301 entre Cerna y Guerrero - Colonia Centro, 84600 Santa Ana
Compare bus companies
Frequently asked questions about traveling from Mexicali to Santa Ana, SON, MX by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Mexicali to Santa Ana?
The cheapest bus tickets from Mexicali to Santa Ana start from $54. The average price for this route is around $54. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Mexicali to Santa Ana?
The average bus trip duration from Mexicali to Santa Ana is 7h 10m, covering a distance of 294 miles (473 km). The quickest bus can get you there in 5h 30m and is operated by Interbus de Sinaloa.
Which bus companies service the Mexicali to Santa Ana route?
Several major bus companies operate on this route with 30 buses available per day, including services from Tufesa, Chihuahuenses, Interbus de Sinaloa, Aguacaliente, Futura.
What is the earliest and latest departure time for the bus from Mexicali to Santa Ana?
The earliest bus departs from Mexicali to Santa Ana at 12:20am. And the latest bus departs at 11:59pm.
What are the CO₂ emissions for the bus trip from Mexicali to Santa Ana?
A bus trip from Mexicali to Santa Ana generates an estimated 12 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Mexicali to Santa Ana?
According to Busbud customers, the highest-rated bus company on this route is Interbus de Sinaloa, with an average rating of 4.0 out of 5 stars based on 4 reviews.
Which bus company has the best Wi-Fi from Mexicali to Santa Ana?
Based on reviews on Busbud, the bus company Tufesa has the best Wi-Fi rating with a score of 3.0.
Which bus company has the most timely service from Mexicali to Santa Ana?
According to Busbud traveller reviews, the most timely bus company on this route is Interbus de Sinaloa, with a punctuality rating of 3.4 out of 5 stars.
Which bus company has the cleanest buses from Mexicali to Santa Ana?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Tufesa, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Mexicali to Santa Ana, SON, MX was searched and found on Jan 10, 2026 with a price of $54To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Mexicali to Santa Ana, SON, MX, as early as possible.
You can expect to pay from $54 to $64 for a bus ticket from Mexicali to Santa Ana, SON, MX based on the last 2 days. You can expect to find the cheapest price for the trip at $54 which is on 2026-01-10.
Usually Tufesa will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
