Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Minneapolis | 632 17th Street North | Cheapest | ||||
| Bus | Minneapolis (U of MN - Huron Blvd) | La Crosse MTU Transit Center | Fastest | ||||
| Bus | MSP Airport T1 (Minneapolis International Airport) | 632 17th Street North | No tags | ||||
| Bus | Minneapolis (U of MN - Huron Blvd) | La Crosse MTU Transit Center | No tags | ||||
| Bus | Minneapolis (U of MN - Huron Blvd) | 632 17th Street North | No tags |
Last refresh of the prices: Yesterday at 8:47 AM CST.
Get from Minneapolis to La Crosse
The journey takes about 4 hours 20 minutes and with fares starting at just $30, it presents an excellent value for a comfortable ride.
Compare bus companies
Founded in 1919, Jefferson Lines provides bus services across the Midwest in the US. Their buses have WiFi, USB plugs, bathrooms, reclining seats, reading lights and GPS tracking. Tickets are non-refundable, but you can change the date by paying a fee. Known for their affordable prices and convenient schedules, if you're looking to travel in the Midwest, Jefferson Lines is the way to go.
Jefferson Lines Minneapolis La Crosse recent customer reviews
First time on bus. Both people in Minneapoles terminal very helpful as I had questions. Driver and assistant also nice.
David S.
Frequently asked questions about traveling from Minneapolis to La Crosse, WI by bus
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Minneapolis to La Crosse, WI was searched and found on Nov 24, 2025 with a price of $32To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Minneapolis to La Crosse, WI, as early as possible.
You can expect to pay from $32 to $91 for a bus ticket from Minneapolis to La Crosse, WI based on the last 2 days. You can expect to find the cheapest price for the trip at $32 which is on 2025-11-26.
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