Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | San Ysidro Bus terminal | Boston (South Station) | Cheapest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | San Ysidro Bus terminal | Boston (South Station) | Fastest | ||||
 | Bus | San Ysidro Bus terminal | Boston (South Station) | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | San Ysidro Bus terminal | Brookline | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | San Ysidro Bus terminal | Brookline | No tags |
Last refresh of the prices: Last Tuesday at 7:01 AM PST.
Get from San Ysidro to Boston
The journey takes about 3 days, 6 hours 55 minutes and with fares starting at just $230, it presents an excellent value for a comfortable ride.
Where are the popular stops in San Ysidro and Boston?
Stops in Boston
- A145 Dartmouth St, Boston, MA 02116, USA
- B100 Legends Way, Boston, MA 02114, USA
- C
Copley Square
115-127 St James Ave, Boston, MA 02116, USA - D
Prudential MBTA Station
220 Huntington Ave, Boston, MA 02115, USA - E
Copley MBTA Station
650 Boylston St, Boston, MA 02116, USA - F
Long Wharf
66 Long Wharf, Boston, MA 02110, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from San Ysidro, CA to Boston, MA, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from San Ysidro to Boston?
The cheapest bus tickets from San Ysidro to Boston start from $230. The average price for this route is around $282. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from San Ysidro to Boston?
The average bus trip duration from San Ysidro to Boston is 3d 6h, covering a distance of 2573 miles (4149 km). The quickest bus can get you there in 3d 7h and is operated by Greyhound.
Which bus companies service the San Ysidro to Boston route?
Several major train operators operate on this route with 7 trains available per day.
What is the earliest and latest departure time for the bus from San Ysidro to Boston?
The earliest bus departs from San Ysidro to Boston at 6:00am. And the latest bus departs at 7:00pm.
What are the CO₂ emissions for the bus trip from San Ysidro to Boston?
A bus trip from San Ysidro to Boston generates an estimated 104 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Ysidro, CA to Boston, MA, US was searched and found on Jan 9, 2026 with a price of $228To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Ysidro, CA to Boston, MA, US, as early as possible.
You can expect to pay from $228 to $512 for a bus ticket from San Ysidro, CA to Boston, MA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $228 which is on 2026-01-09.
Top traveled bus routes
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