How much is the bus ticket from Syracuse to Indianapolis?

The cheapest bus tickets from Syracuse to Indianapolis start from $123. The average price for this route is around $182. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Syracuse to Indianapolis?

The average bus trip duration from Syracuse to Indianapolis is 1d , covering a distance of 565 miles (911 km). The quickest bus can get you there in 21h 40m and is operated by Greyhound .

Which bus companies service the Syracuse to Indianapolis route?

Several major bus companies operate on this route with 3 buses available per day, including services from Greyhound , FlixBus .

What is the earliest and latest departure time for the bus from Syracuse to Indianapolis?

The earliest bus departs from Syracuse to Indianapolis at 1:15am. And the latest bus departs at 9:00pm.

What are the CO₂ emissions for the bus trip from Syracuse to Indianapolis?

A bus trip from Syracuse to Indianapolis generates an estimated 23 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

What is the best bus company from Syracuse to Indianapolis?

According to Busbud customers, the highest-rated bus company on this route is Greyhound , with an average rating of 3.5 out of 5 stars based on 87412 reviews.

Which bus company has the best Wi-Fi from Syracuse to Indianapolis?

Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.

Which bus company has the most timely service from Syracuse to Indianapolis?

According to Busbud traveller reviews, the most timely bus company on this route is FlixBus , with a punctuality rating of 3.9 out of 5 stars.

Which bus company has the cleanest buses from Syracuse to Indianapolis?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus , with a cleanliness rating of 4.1 out of 5 stars.

Bus Syracuse to Indianapolis from $116 | Refundable Tickets

Previously seen trips

Next departures for Syracuse to Indianapolis on December 14
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound + FlixBus	Bus	9:25am	Syracuse (Regional Transportation Center)	1d 3h	1:15pm	Downtown Transit Center	No tags
Greyhound + FlixBus	Bus	2:20pm	Syracuse (Regional Transportation Center)	1d 8h	11:15pm	Downtown Transit Center	No tags
	Bus	9:00pm	Syracuse (Regional Transportation Center)	21h 20m	6:20pm	Indianapolis Bus Station	No tags
	Bus	12:20am	Syracuse (Regional Transportation Center)	1d 1h	2:15am	Indianapolis Bus Station	No tags
Greyhound + FlixBus	Bus	4:30am	Syracuse (Regional Transportation Center)	1d 3h	8:00am	Downtown Transit Center	No tags

Compare 2 ways to go from Syracuse to Indianapolis

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach Indianapolis. The journey takes about 1 day, 20 minutes and with fares starting at just $123, it presents an excellent value for a comfortable ride.

3bus per day

1d Average Duration

565 milesDistance

23kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$123 - $316	Average Duration1d	CO₂ emissions 23kg CO₂e
Train	Average Price$159 - $275	Average Duration1d 1h	CO₂ emissions 83kg CO₂e

Where are the popular stops in Syracuse and Indianapolis?

Stops in Syracuse

A
Regional Transportation Center
1 Walsh Circle Ste 30, Syracuse, NY 13208
Visit page
B
Syracuse Airport
Visit page
C
Syracuse University
Bus stops at Schine Student Center across the street from the Sheraton Parking Garage., Schine Student Center, 303 University Pl, Syracuse, NY 13210
Visit page
D
Syracuse University - Lyman Hall
College Place, Syracuse, NY 13210, USA
E
New York State Fairgrounds
581 State Fair Blvd, Syracuse, NY 13209, USA
F
Syracuse, NY
349-399 US-11, Syracuse, NY 13202, USA

Stops in Indianapolis

A
Greyhound Amtrak Station
350 S Illinois St, Indianapolis, IN 46225
Visit page

Compare bus companies

Greyhound

3.5/587,430 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

FlixBus

3.5/511,601 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Big Sky

Frequently asked questions about traveling from Syracuse, US to Indianapolis by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Syracuse to Indianapolis?
The cheapest bus tickets from Syracuse to Indianapolis start from $123. The average price for this route is around $182. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Syracuse to Indianapolis?
The average bus trip duration from Syracuse to Indianapolis is 1d , covering a distance of 565 miles (911 km). The quickest bus can get you there in 21h 40m and is operated by Greyhound.
Which bus companies service the Syracuse to Indianapolis route?
Several major bus companies operate on this route with 3 buses available per day, including services from Greyhound, FlixBus.
What is the earliest and latest departure time for the bus from Syracuse to Indianapolis?
The earliest bus departs from Syracuse to Indianapolis at 1:15am. And the latest bus departs at 9:00pm.
What are the CO₂ emissions for the bus trip from Syracuse to Indianapolis?
A bus trip from Syracuse to Indianapolis generates an estimated 23 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Syracuse to Indianapolis?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87412 reviews.
Which bus company has the best Wi-Fi from Syracuse to Indianapolis?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Syracuse to Indianapolis?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Syracuse to Indianapolis?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

12/11

$119

12/12

$142

Today

$209

12/14

No data

12/15

$116

12/16

$125

12/17

$129

12/18

No data

The cheapest trip from Syracuse, US to Indianapolis was searched and found on Dec 15, 2025 with a price of $116

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Indianapolis, as early as possible.

You can expect to pay from $116 to $251 for a bus ticket from Syracuse, US to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $116 which is on 2025-12-15.