Bus Tickets from Portland, OR to Florence, SC, US

Previously seen trips

Next departures for Portland to Florence on November 18
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound
Bus
Portland Union Station
Florence, SCNo tags
Greyhound + FlixBus
Bus
Portland Union Station
Florence, SCNo tags
FlixBus + Greyhound
Bus
Portland Union Station
Florence, SCNo tags
GreyhoundBus
Portland Curbside Bus Stop
Bus stationNo tags
FlixBus + Greyhound
Bus
Portland Curbside Bus Stop
Florence, SCNo tags

Compare 2 ways to go from Portland to Florence

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Florence. The journey takes about 3 days, 14 hours 30 minutes, and with fares starting at just $342, it presents an excellent value for a comfortable ride.

4bus per day
3d 14hAverage Duration
3822 kmDistance
96kgCO₂ emissions
Bus
Average Price$342 - $434Average Duration3d 14h
96kg CO₂e
Train
Average Price$1,272 - $1,272Average Duration4d 9h
348kg CO₂e

Frequently asked questions about travelling from Portland, OR to Florence, SC, US by bus

  1. What is the distance between Portland and Florence?

    It's about 3835 km (2378 miles) from Portland to Florence.

  2. What are the departure and arrival locations for buses traveling from Portland to Florence?

    Buses traveling this route start their trip at Portland Union Station, in Portland, and end it at Florence Bus Station, in Florence.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
11-16
No data
11-17
No data
Today
No data
11-19
No data
11-20
No data
11-21
No data
11-22
$347
11-23
No data
busbud logoThe cheapest trip from Portland, OR to Florence, SC, US was searched and found on Nov 22, 2025 with a price of $347

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Portland, OR to Florence, SC, US, as early as possible.

You can expect to pay from $347 to $3,765 for a bus ticket from Portland, OR to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $347 which is on 2025-11-22.

Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

What's the cheapest way to go from Portland, OR to Florence, SC, US?

busbud logoThe bus is the cheapest travel choice for this destination

People from around the world trust Busbud

‌

Popular Buses Connecting Portland

Buses Leaving from Portland

Buses Going to Portland

Popular Buses Connecting Florence

Buses Leaving from Florence

Buses Going to Florence