Bus Tickets from Des Moines to Louisville

Previously seen trips

Next departures for Des Moines to Louisville on September 25
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound
Des Moines (Subway)
Louisville, KYNo tags
FlixBus + Greyhound
Des Moines (Subway)
Louisville, KYNo tags
Greyhound + FlixBus
Des Moines (Subway)
Louisville, KYNo tags
FlixBus + Greyhound
Des Moines (Subway)
Louisville, KYNo tags
FlixBus + Greyhound
Des Moines (Subway)
Louisville, KYNo tags

Accepted payments

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  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Des Moines to Louisville: Trip Overview

Average ticket price$116
Average bus trip duration15h 30m
Number of daily buses1
Earliest bus departure5:30am
Distance474 miles (764 km)

Des Moines to Louisville Bus

With Busbud, comparing and booking tickets for a bus from Des Moines to Louisville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Des Moines to Louisville will be provided by the most trusted bus companies.

Discover how much the bus trip from Des Moines to Louisville will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip Des Moines - Louisville

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09/22
No data
09/23
$108
Today
No data
09/25
No data
09/26
No data
09/27
No data
09/28
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09/29
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busbud logoThe cheapest trip from Des Moines to Louisville was searched and found on Sep 23, 2025 with a price of $108

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Louisville, as early as possible.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Des Moines to Louisville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Des Moines to Louisville, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Des Moines to Louisville will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from Des Moines to Louisville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

Will you be returning to Des Moines by bus?

Bus from Louisville to Des Moines

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