Bus Tickets from Greenville, SC to Gainesville, FL

Previously seen trips

Next departures for Greenville to Gainesville on October 13
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus
1116 Woodruff Rd
Rosa Parks StationNo tags
Greyhound + FlixBus
1116 Woodruff Rd
Gainesville Bus StopNo tags
FlixBus + Greyhound
1116 Woodruff Rd
Rosa Parks StationNo tags
Greyhound + FlixBus
1116 Woodruff Rd
Rosa Parks StationNo tags
FlixBus + Greyhound
1116 Woodruff Rd
Gainesville Bus StopNo tags

Accepted payments

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  • China Union Pay
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  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Greenville, SC to Gainesville, FL: Trip Overview

Average ticket price$72
Average bus trip duration15h 15m
Number of daily buses8
Earliest bus departure7:40am
Distance359 miles (579 km)
Latest bus departure10:00pm

Greenville to Gainesville Bus

With Busbud, comparing and booking tickets for a bus from Greenville to Gainesville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Greenville to Gainesville from the most reliable bus companies operating this trip.

Discover how much the bus trip from Greenville to Gainesville will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip Greenville, SC - Gainesville, FL

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10/11
$57
10/12
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Today
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10/14
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10/15
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10/16
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10/18
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busbud logoThe cheapest trip from Greenville, SC to Gainesville, FL was searched and found on Oct 11, 2025 with a price of $57

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Gainesville, FL, as early as possible.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Greenville to Gainesville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Greenville to Gainesville, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Greenville to Gainesville will emit less CO2 than a car or an airplane.

Tune out to the fine sounds of your best music playlist on your bus trip from Greenville to Gainesville while indulging in miles on end of beautiful scenic views.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

Will you be returning to Greenville, SC by bus?

Bus from Gainesville, FL to Greenville, SC

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