Bus Tickets from Philadelphia, PA to Greenville, SC

Find affordable bus tickets from Philadelphia, PA to Greenville, SC with flexible options. Book your trip now

Join 75M+ travelers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every step.
Cancel anytime and receive a 100% refund, no reason needed.
TodayJul 16
from $131
TomorrowJul 17
from $131
FriJul 18
from $104
SatJul 19
from $112
SunJul 20
from $117
MonJul 21
from $107
TueJul 22
from $99
WedJul 23

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: July 17 at
    Departure city: Philadelphia
    Departure location: 199 Spring Garden St.
    Arrival time: July 18 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: July 17 at
    Departure city: Philadelphia
    Departure location: Philadelphia, 199 Spring Garden St
    Arrival time: July 18 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: July 17 at
    Departure city: Philadelphia
    Departure location: 199 Spring Garden St.
    Arrival time: July 18 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: July 17 at
    Departure city: Philadelphia
    Departure location: Philadelphia, 199 Spring Garden St
    Arrival time: July 18 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: July 17 at
    Departure city: Philadelphia
    Departure location: Schuylkill & Walnut
    Arrival time: July 18 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from Philadelphia to Greenville.

Bus
Average Price$65 - $319Average Duration18h 35m
21kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average Price$100 - $694Average Duration13h 46m
78kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the bus from Philadelphia to Greenville

Among the sustainable travel choices, the bus stands out as the good way to reach Greenville. The journey takes about 18 hours 35 minutes and with fares starting at just $65, it presents an excellent value for a comfortable ride.

15bus per day
18h 35mAverage Duration
$65Cheapest ticket
21kgCO₂ emissions

Bus Philadelphia to Greenville: Trip Overview

Average ticket price$101
Average bus trip duration18h 35m
Number of daily buses15
Earliest bus departure1:50am
Distance532 miles (858 km)
Latest bus departure10:30pm

Philadelphia to Greenville Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Philadelphia to Greenville.

We make it our job to connect you with the most dependable bus companies that cover bus service from Philadelphia to Greenville.

Discover how much the bus trip from Philadelphia to Greenville will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip Philadelphia, PA - Greenville, SC

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
07/14
$131
07/15
$112
Today
$123
07/17
$123
07/18
$96
07/19
$105
07/20
$109
07/21
$99
busbud logoThe cheapest trip from Philadelphia to Greenville was searched and found on Jul 18, 2025 with a price of $96

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Philadelphia to Greenville, as early as possible.

You can expect to pay from $96 to $259 for a bus ticket from Philadelphia to Greenville based on the last 2 days. You can expect to find the cheapest price for the trip at $96 which is on 2025-07-18.

Usually FlixBus Inc. will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Philadelphia to Greenville but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Philadelphia to Greenville.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Philadelphia to Greenville will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from Philadelphia to Greenville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

What's the cheapest way to go from Philadelphia to Greenville?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Philadelphia by bus?

Bus from Philadelphia to Greenville

You can also go to Greenville, SC by train

Train from Philadelphia, PA to Greenville, SC

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

People from around the world trust Busbud

‌

Popular Buses Connecting Philadelphia

Buses Leaving from Philadelphia

Buses Going to Philadelphia

Popular Buses Connecting Greenville

Buses Leaving from Greenville

Buses Going to Greenville