Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Port St. Lucie (Park & Ride) | Rosa Parks Station | Cheapest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Port St. Lucie (Park & Ride) | Gainesville Bus Stop | Fastest | ||||
 | Bus | Port St. Lucie (Park & Ride) | Rosa Parks Station | No tags |
Last refresh of the prices: Last Tuesday at 3:36 PM EST.
Get from Port Saint Lucie to Gainesville
This route is served by bus only
The journey takes about 8 hours and with fares starting at just $36, it presents an excellent value for a comfortable ride.
3bus per day
8hAverage Duration
201 milesDistance
8kgCO₂ emissions
Compare bus companies
US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad
Where are the popular stops in Port Saint Lucie and Gainesville?
Stops in Port Saint Lucie
- A
Port St Lucie Mobil Gas Bus Stop
1820 Sw Fountainview Blvd, Port Saint Lucie, FL 34986 - B
Port Saint Lucie - Wendys
1790 SW St Lucie W Blvd, Port St Lucie, FL 34986 - C
Port Saint LucieService Plaza
Florida's Turnpike, Milepost 144, Port St Lucie, FL 34984, USA - D
Port Saint Lucie Bus Stop
2198 SW Gatlin Blvd. Port St. Lucie, FL 34953
Stops in Gainesville
- A700 SE 3rd St, Gainesville, FL 32601
- B3509 SW Williston Rd, Gainesville, FL 32608, USA
- C101 NE 23rd Ave, Gainesville, FL 32609
Frequently asked questions about traveling from Port Saint Lucie to Gainesville, FL by bus
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/18
No data
11/19
No data
Today
No data
11/21
No data
11/22
No data
11/23
No data
11/24
$76
11/25
No data
The cheapest trip from Port Saint Lucie to Gainesville, FL was searched and found on Nov 24, 2025 with a price of $76To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Port Saint Lucie to Gainesville, FL, as early as possible.
You can expect to pay from $76 to $76 for a bus ticket from Port Saint Lucie to Gainesville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at $76 which is on 2025-11-24.
Top traveled bus routes
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Popular bus departures from Port Saint Lucie
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