Bus Tickets from San Francisco, US to Des Moines

Previously seen trips

Next departures for San Francisco to Des Moines on October 13
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound
San Francisco Bus Station
Des Moines (Subway)No tags
FlixBus + Greyhound
409 Townsend St, SF
Des Moines (Subway)No tags
Greyhound
San Francisco Bus Station
Des Moines (Subway)No tags
Greyhound + FlixBus
409 Townsend St, SF
Des Moines (Subway)No tags
FlixBus + Greyhound
San Francisco Bus Station
Des Moines (Subway)No tags

Accepted payments

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  • China Union Pay
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  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus San Francisco, US to Des Moines: Trip Overview

Average Ticket PriceUS$266
Average Bus Trip Duration2d 23h
Number of daily buses3
Earliest bus departure12:05pm
Distance2489 km
Latest bus departure11:25pm

San Francisco to Des Moines Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from San Francisco to Des Moines.

We make it our job to connect you with the most dependable bus companies that cover bus service from San Francisco to Des Moines.

From cheap bus tickets to more luxurious buses travelling from San Francisco to Des Moines, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip San Francisco, US - Des Moines

  1. What is the distance between San Francisco and Des Moines?

    The distance covered from San Francisco to Des Moines is 2493 km (1546 miles).

  2. What are the departure and arrival locations for buses traveling from San Francisco to Des Moines?

    Buses traveling this route start their trip at Hyde/Beach (Fisherman's Wharf), in San Francisco, and end it at Jefferson/Trailways Depot, in Des Moines.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10-11
US$223
10-12
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Today
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10-14
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10-15
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10-16
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10-17
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10-18
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busbud logoThe cheapest trip from San Francisco, US to Des Moines was searched and found on Oct 11, 2025 with a price of US$223

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Francisco, US to Des Moines, as early as possible.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from San Francisco to Des Moines but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from San Francisco to Des Moines.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from San Francisco to Des Moines that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from San Francisco to Des Moines.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Will you be returning to San Francisco, US by bus?

Bus from Des Moines to San Francisco, US

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