Bus Tickets from Key West to Panama City, US

Previously seen trips

Next departures for Key West to Panama City on November 1
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound + FlixBus
    		Caroline St
    		Panama City Beach StationNo tags
    Greyhound
      		Key West Bus Station
      		Panama City Beach StationNo tags
      Greyhound + FlixBus
        		Caroline St
        		Panama City Beach StationNo tags
        Greyhound
          		Key West Bus Station
          		Panama City Beach StationNo tags
          Greyhound
            		Key West Bus Station
            		Panama City Beach StationNo tags

            Accepted payments

            • Visa
            • MasterCard
            • American Express
            • China Union Pay
            • Diners Club Canada
            • Discover Click to Pay
            • JCB payment
            • Klarna (Pay over time)
            • Google Pay

            Get from Key West to Panama City

            This route is served by bus only

            The journey takes about 22 hours, and with fares starting at just US$148, it presents an excellent value for a comfortable ride.

            1bus per day
            22hAverage Duration
            742 kmDistance
            19kgCO₂ emissions

            Bus Key West to Panama City, US: Trip Overview

            Average Ticket PriceUS$148
            Average Bus Trip Duration22h
            Number of daily buses1
            Earliest bus departure5:00pm
            Distance741 km

            Key West to Panama City Bus

            With Busbud, comparing and booking tickets for a bus from Key West to Panama City is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

            Bus service from Key West to Panama City will be provided by the most trusted bus companies.

            Whether it is cheap bus tickets or more luxurious buses going to Panama City from Key West, we help you find what you're looking for based on how much of a budget you have.

            Frequently asked questions on the trip Key West - Panama City, US

            1. What is the travel distance from Key West to Panama City?

              The distance between Key West and Panama City is approximately 733 km (455 miles).

            2. What are the departure and arrival locations for buses traveling from Key West to Panama City?

              Buses departing from Caroline St in Key West will take you to Panama City Greyhound Bus Station in Panama City.

            Find cheapest prices for buses

            Price is for a one-way ticket for one passenger and based on past searches.

            Best price found
            10-29
            No data
            10-30
            US$141
            Today
            No data
            11-01
            No data
            11-02
            No data
            11-03
            No data
            11-04
            No data
            11-05
            No data
            busbud logoThe cheapest trip from Key West to Panama City, US was searched and found on Oct 30, 2025 with a price of US$141

            To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Key West to Panama City, US, as early as possible.

            About Bus Travel

            Bus Travel Tips

            Meet and talk to locals at the bus stations while travelling from Key West to Panama City.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

            Much more than a mere vehicle taking you from Key West to Panama City, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

            Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Key West to Panama City.

            Make a music playlist for your bus ride from Key West to Panama City, and enjoy the scenery to tunes from your own personal soundtrack.

            Did you know?

            Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

            The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

            9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

            Will you be returning to Key West by bus?

            Bus from Panama City, US to Key West

            Why choose Busbud?

            The Best Way To Book Bus and Train Tickets

            Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

            People from around the world trust Busbud

            ‌

            Popular Buses Connecting Key West

            Buses Leaving from Key West

            Buses Going to Key West

            Popular Buses Connecting Panama City

            Buses Leaving from Panama City

            Buses Going to Panama City