Bus Tickets from Key West to Panama City, US

Previously seen trips

Next departures for Key West to Panama City on November 1
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound + FlixBus
    		Caroline St
    		Panama City Beach StationNo tags
    Greyhound
      		Key West Bus Station
      		Panama City Beach StationNo tags
      Greyhound + FlixBus
        		Caroline St
        		Panama City Beach StationNo tags
        Greyhound
          		Key West Bus Station
          		Panama City Beach StationNo tags
          Greyhound
            		Key West Bus Station
            		Panama City Beach StationNo tags

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            Get from Key West to Panama City

            This route is served by bus only

            The journey takes about 22 hours and with fares starting at just $148, it presents an excellent value for a comfortable ride.

            1bus per day
            22hAverage Duration
            460 milesDistance
            19kgCO₂ emissions

            Bus Key West to Panama City, US: Trip Overview

            Average ticket price$148
            Average bus trip duration22h
            Number of daily buses1
            Earliest bus departure5:00pm
            Distance460 miles (741 km)

            Key West to Panama City Bus

            With Busbud, comparing and booking tickets for a bus from Key West to Panama City is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

            Bus service from Key West to Panama City will be provided by the most trusted bus companies.

            Whether it is cheap bus tickets or more luxurious buses going to Panama City from Key West, we help you find what you're looking for based on how much of a budget you have.

            Frequently asked questions for your trip Key West - Panama City, US

            Find cheapest prices for buses

            Price is for a one-way ticket for one passenger and based on past searches.

            Best price found
            10/30
            $141
            10/31
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            Today
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            11/02
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            11/03
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            11/04
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            11/05
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            11/06
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            busbud logoThe cheapest trip from Key West to Panama City, US was searched and found on Oct 30, 2025 with a price of $141

            To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Key West to Panama City, US, as early as possible.

            About Bus Travel

            Bus Travel Tips

            Meet and talk to locals at the bus stations while traveling from Key West to Panama City.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

            Much more than a mere vehicle taking you from Key West to Panama City, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

            Buses are energy-efficient. Carrying a passenger over 100 kms by bus only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Key West to Panama City.

            Make a music playlist for your bus ride from Key West to Panama City, and enjoy the scenery to tunes from your own personal soundtrack.

            Did you know?

            Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

            The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

            9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

            Will you be returning to Key West by bus?

            Bus from Panama City, US to Key West

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