Bus Tickets from San Diego, CA, US to Santa Ana, US

TodayJul 31
from $25
TomorrowAug 1
from $25
SatAug 2
from $25
SunAug 3
from $26
MonAug 4
from $25
TueAug 5
from $24
WedAug 6
from $24
ThuAug 7
from $24

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: August 1 at
    Departure city: San Diego
    Departure location: San Diego (Old Town-FlixBus)
    Arrival time: August 1 at
    Destination city: Santa Ana
    Destination location: UC Irvine (Crawford Hall)
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: August 1 at
    Departure city: San Diego
    Departure location: UCSD Health La Jolla Station
    Arrival time: August 1 at
    Destination city: Santa Ana
    Destination location: UC Irvine (Crawford Hall)
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: August 1 at
    Departure city: San Diego
    Departure location: San Diego (Old Town-FlixBus)
    Arrival time: August 1 at
    Destination city: Santa Ana
    Destination location: Anaheim Regional Transportation Intermodal Center
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: August 1 at
    Departure city: San Diego
    Departure location: Greyhound Bus Stop
    Arrival time: August 1 at
    Destination city: Santa Ana
    Destination location: Anaheim Regional Transportation Intermodal Center
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 1 at
    Departure city: San Diego
    Departure location: Cross Border Xpress CBX (USA)
    Arrival time: August 1 at
    Destination city: Santa Ana
    Destination location: Santa Ana E Santa Ana Blvd
    Operated by: Los LimousinesLos Limousines
    Vehicle: BusDuration:

Accepted payments

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Compare 2 ways to go from San Diego to Santa Ana.

Bus
Average Price$23 - $46Average Duration2h 15m
4kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Shuttle
Average Price$92 - $92Average Duration9h 10m
4kg CO₂e4 out of 5 stars
busbud logoBusbud recommends taking the bus from San Diego to Santa Ana

Among the sustainable travel choices, the bus stands out as the good way to reach Santa Ana. The journey takes about 2 hours 15 minutes and with fares starting at just $23, it presents an excellent value for a comfortable ride.

24bus per day
2h 15mAverage Duration
$23Cheapest ticket
4kgCO₂ emissions

Bus San Diego, CA, US to Santa Ana, US: Trip Overview

Average ticket price$45
Average bus trip duration2h 15m
Number of daily buses24
Earliest bus departure12:30am
Distance98 miles (157 km)
Latest bus departure10:30pm

San Diego to Santa Ana Bus

With Busbud, comparing and booking tickets for a bus from San Diego to Santa Ana is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from San Diego to Santa Ana from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses traveling from San Diego to Santa Ana, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip San Diego, CA, US - Santa Ana, US

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
07/29
$19
07/30
$22
Today
$18
08/01
$17
08/02
$17
08/03
$18
08/04
$17
08/05
$16
busbud logoThe cheapest trip from San Diego, CA, US to Santa Ana, US was searched and found on Aug 5, 2025 with a price of $16

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Santa Ana, US, as early as possible.

You can expect to pay from $16 to $43 for a bus ticket from San Diego, CA, US to Santa Ana, US based on the last 2 days. You can expect to find the cheapest price for the trip at $16 which is on 2025-08-05.

Usually LLIO will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from San Diego to Santa Ana.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from San Diego to Santa Ana, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from San Diego to Santa Ana that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from San Diego to Santa Ana while indulging in miles on end of beautiful scenic views.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Will you be returning to San Diego, CA, US by bus?

Bus from San Diego, CA, US to Santa Ana, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

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