Bus Tickets from Spartanburg to Buffalo, NY

Find affordable bus tickets from Spartanburg to Buffalo, NY with flexible options. Book your trip now

Join 75M+ travelers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every step.
Cancel anytime and receive a 100% refund, no reason needed.
SatJun 28
from $160
SunJun 29
MonJun 30
TueJul 1
WedJul 2
ThuJul 3
from $147
FriJul 4
SatJul 5

Cheap buses leaving Thursday

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: July 3 at
    Departure city: Spartanburg
    Departure location: Spartanburg
    Arrival time: July 5 at
    Destination city: Buffalo
    Destination location: Buffalo (BUF) Airport
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: July 3 at
    Departure city: Spartanburg
    Departure location: Spartanburg
    Arrival time: July 4 at
    Destination city: Buffalo
    Destination location: Niagara Frontier Transportation Authority
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: July 3 at
    Departure city: Spartanburg
    Departure location: Spartanburg
    Arrival time: July 4 at
    Destination city: Buffalo
    Destination location: Niagara Frontier Transportation Authority
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: July 3 at
    Departure city: Spartanburg
    Departure location: Spartanburg
    Arrival time: July 4 at
    Destination city: Buffalo
    Destination location: Niagara Frontier Transportation Authority
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: July 3 at
    Departure city: Spartanburg
    Departure location: Spartanburg
    Arrival time: July 4 at
    Destination city: Buffalo
    Destination location: Niagara Frontier Transportation Authority
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Spartanburg to Buffalo: Trip Overview

Average ticket price$161
Average bus trip duration1d 3h
Number of daily buses8
Earliest bus departure3:40am
Distance569 miles (917 km)
Latest bus departure9:00pm

Spartanburg to Buffalo Bus

With Busbud, comparing and booking tickets for a bus from Spartanburg to Buffalo is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Spartanburg to Buffalo will be provided by the most trusted bus companies.

Whether it is cheap bus tickets or more luxurious buses going to Buffalo from Spartanburg, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Spartanburg - Buffalo, NY

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06/24
No data
06/25
$133
Today
No data
06/27
No data
06/28
$161
06/29
No data
06/30
No data
07/01
No data
busbud logoThe cheapest trip from Spartanburg to Buffalo was searched and found on Jun 25, 2025 with a price of $133

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Spartanburg to Buffalo, as early as possible.

You can expect to pay from $133 to $176 for a bus ticket from Spartanburg to Buffalo based on the last 2 days. You can expect to find the cheapest price for the trip at $161 which is on 2025-06-28.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Spartanburg to Buffalo.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Spartanburg to Buffalo, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Spartanburg to Buffalo.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Spartanburg to Buffalo.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to Spartanburg by bus?

Bus from Spartanburg to Buffalo

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travelers find a bus, plot routes, and book intercity bus tickets all over the world. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Buses Connecting Spartanburg

Buses Leaving from Spartanburg

Buses Going to Spartanburg

Popular Buses Connecting Buffalo

Buses Leaving from Buffalo

Buses Going to Buffalo