Bus Tickets from Rochester, NY, US to Florence, SC, US

Next departures

Next departures for Rochester to Florence on November 4
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
    		Rochester
    		Bus stationCheapest
    FlixBus
      		Rochester
      		Florence, SCFastest

      Last refresh of the prices: Yesterday at 7:10 PM EST.

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      Compare 2 ways to go from Rochester to Florence

      We recommend taking the train

      Among the sustainable travel choices, the train stands out as a good way to reach Florence. The journey takes about 21 hours 30 minutes, and with fares starting at just $394, it presents an excellent value for a comfortable ride.

      1train per day
      21h 30mAverage Duration
      1014 kmDistance
      92kgCO₂ emissions
      Bus
      		Average Price$144 - $336Average Duration1d 4h
      25kg CO₂e
      Train
      		Average Price$394 - $536Average Duration21h 30m
      92kg CO₂e

      Bus Rochester, NY, US to Florence, SC, US: Trip Overview

      Average Ticket Price$250
      Average Bus Trip Duration1d 4h
      Number of daily buses2
      Earliest bus departure12:35am
      Distance1015 km
      Latest bus departure11:35pm

      Rochester to Florence Bus

      Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Rochester to Florence.

      We make sure you can find a bus service from Rochester to Florence from the most reliable bus companies operating this trip.

      Whether it is cheap bus tickets or more luxurious buses going to Florence from Rochester, we help you find what you're looking for based on how much of a budget you have.

      Frequently asked questions on the trip Rochester, NY, US - Florence, SC, US

      1. What is the distance between Rochester and Florence?

        The distance covered from Rochester to Florence is 1012 km (627 miles).

      2. What are the departure and arrival locations for buses traveling from Rochester to Florence?

        Buses traveling this route start their trip at Bus Station, in Rochester, and end it at Florence Bus Station, in Florence.

      Find cheapest prices for buses

      Price is for a one-way ticket for one passenger and based on past searches.

      Best price found
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      $258
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      busbud logoThe cheapest trip from Rochester, NY, US to Florence, SC, US was searched and found on Nov 4, 2025 with a price of $258

      To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rochester, NY, US to Florence, SC, US, as early as possible.

      About Bus Travel

      Bus Travel Tips

      If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Rochester to Florence but it'll also be endearing to native speakers who will surely appreciate your effort.

      Start sightseeing the minute your bus leaves the station. If you're on the night bus from Rochester to Florence, get comfy and count the stars.

      Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Rochester to Florence.

      Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Rochester to Florence.

      Did you know?

      9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

      Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

      The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

      What's the cheapest way to go from Rochester, NY, US to Florence, SC, US?

      busbud logoThe bus is the cheapest travel choice for this destination

      Will you be returning to Rochester, NY, US by bus?

      Bus from Florence, SC, US to Rochester, NY, US

      You can also go to Florence, SC, US by train

      Train from Rochester, NY, US to Florence, SC, US

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