Bus Tickets from Rochester, NY, US to Florence, SC, US

Next departures

Next departures for Rochester to Florence on November 4
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
    Rochester
    Bus stationCheapest
    FlixBus + Greyhound Lines, Inc.
      Rochester
      Bus stationFastest
      FlixBus
        Rochester
        Florence, SCNo tags

        Last refresh of the prices: Yesterday at 7:10 PM EST.

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        Compare 2 ways to go from Rochester to Florence

        We recommend taking the train

        Among the sustainable travel choices, the train stands out as the good way to reach Florence. The journey takes about 21 hours 30 minutes and with fares starting at just $274, it presents an excellent value for a comfortable ride.

        1train per day
        21h 30mAverage Duration
        629 milesDistance
        92kgCO₂ emissions
        Average Price$100 - $234Average Duration1d 4h
        25kg CO₂e
        Average Price$274 - $372Average Duration21h 30m
        92kg CO₂e

        Bus Rochester, NY, US to Florence, SC, US: Trip Overview

        Average ticket price$174
        Average bus trip duration1d 4h
        Number of daily buses2
        Earliest bus departure12:35am
        Distance630 miles (1015 km)
        Latest bus departure11:35pm

        Rochester to Florence Bus

        Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Rochester to Florence.

        We make sure you can find a bus service from Rochester to Florence from the most reliable bus companies operating this trip.

        Whether it is cheap bus tickets or more luxurious buses going to Florence from Rochester, we help you find what you're looking for based on how much of a budget you have.

        Frequently asked questions for your trip Rochester, NY, US - Florence, SC, US

        Find cheapest prices for buses

        Price is for a one-way ticket for one passenger and based on past searches.

        Best price found
        11/02
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        Today
        $179
        11/05
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        busbud logoThe cheapest trip from Rochester, NY, US to Florence, SC, US was searched and found on Nov 4, 2025 with a price of $179

        To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rochester, NY, US to Florence, SC, US, as early as possible.

        About Bus Travel

        Bus Travel Tips

        If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Rochester to Florence but it'll also be endearing to native speakers who will surely appreciate your effort.

        Start sightseeing the minute your bus leaves the station. If you're on the night bus from Rochester to Florence, get comfy and count the stars.

        Buses are energy-efficient. Carrying a passenger over 100 kms by bus only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Rochester to Florence.

        Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Rochester to Florence.

        Did you know?

        9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

        Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

        The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

        What's the cheapest way to go from Rochester, NY, US to Florence, SC, US?

        busbud logoThe bus is the cheapest travel choice for this destination

        Will you be returning to Rochester, NY, US by bus?

        Bus from Florence, SC, US to Rochester, NY, US

        You can also go to Florence, SC, US by train

        Train from Rochester, NY, US to Florence, SC, US

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