Bus Tickets from Iowa City to St. Louis

Previously seen trips

Next departures for Iowa City to St. Louis on October 10
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound
Iowa City
Gateway StationNo tags
Burlington Trailways
Iowa City
Saint LouisNo tags
Burlington Trailways
Iowa City
STL AirportNo tags
Greyhound
Iowa City
Gateway StationNo tags
Burlington Trailways
Iowa City
Saint LouisNo tags

Accepted payments

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Bus Iowa City to St. Louis: Trip Overview

Average ticket price$112
Average bus trip duration15h 20m
Number of daily buses1
Earliest bus departure7:50am
Distance221 miles (355 km)
Latest bus departure1:55pm

Iowa City to St. Louis Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Iowa City to St. Louis.

Bus service from Iowa City to St. Louis will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses traveling from Iowa City to St. Louis, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip Iowa City - St. Louis

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10/08
$111
10/09
No data
Today
$121
10/11
No data
10/12
No data
10/13
$128
10/14
No data
10/15
$116
busbud logoThe cheapest trip from Iowa City to St. Louis was searched and found on Oct 8, 2025 with a price of $111

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Iowa City to St. Louis, as early as possible.

You can expect to pay from $111 to $128 for a bus ticket from Iowa City to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $116 which is on 2025-10-15.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Iowa City to St. Louis but it'll also be endearing to native speakers who will surely appreciate your effort.

Much more than a mere vehicle taking you from Iowa City to St. Louis, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Iowa City to St. Louis that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Iowa City to St. Louis.

Did you know?

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Will you be returning to Iowa City by bus?

Bus from St. Louis to Iowa City

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

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