Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Mesa Bus Stop | Anaheim Regional Transportation Intermodal Center | CheapestFastest | ||||
| Bus | Mesa Bus Stop | Santa Ana Bus Station | No tags |
Last refresh of the prices: Last Friday at 9:19 AM MST.
Get from Mesa to Santa Ana
The journey takes about 12 hours and with fares starting at just $70, it presents an excellent value for a comfortable ride.
Where are the popular stops in Mesa and Santa Ana?
Stops in Mesa
- A
Mesa Bus Station
1423 S Country Club , Mesa, AZ 85210, USA
Stops in Santa Ana
- A
Santa Ana Greyhound Bus Station
1000 E Santa Ana Blvd, Santa Ana, CA 92701 - B
602 S Main St
602 S Main St, Santa Ana, CA 92701, USA
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Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Mesa to Santa Ana, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Mesa to Santa Ana?
The cheapest bus tickets from Mesa to Santa Ana start from $70. The average price for this route is around $71. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Mesa to Santa Ana?
The average bus trip duration from Mesa to Santa Ana is 12h, covering a distance of 348 miles (562 km). The quickest bus can get you there in 11h 40m and is operated by Greyhound.
Which bus companies service the Mesa to Santa Ana route?
Several major train operators operate on this route with 3 trains available per day.
What is the earliest and latest departure time for the bus from Mesa to Santa Ana?
The earliest bus departs from Mesa to Santa Ana at 9:10pm. And the latest bus departs at 9:10pm.
What are the CO₂ emissions for the bus trip from Mesa to Santa Ana?
A bus trip from Mesa to Santa Ana generates an estimated 14 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Mesa to Santa Ana, US was searched and found on Dec 9, 2025 with a price of $63To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Mesa to Santa Ana, US, as early as possible.
You can expect to pay from $63 to $102 for a bus ticket from Mesa to Santa Ana, US based on the last 2 days. You can expect to find the cheapest price for the trip at $63 which is on 2025-12-09.
