Next departures for Rochester to Chicago on November 20
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Rochester
Chicago 95Th & Dan Ryan
Cheapest
Bus
Rochester
Downtown Greyhound Station
Fastest
Bus
Rochester
537-517 W. Jackson Blvd
No tags
Next departures for Rochester to Chicago on November 21
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Rochester
Chicago 95Th & Dan Ryan
Cheapest
Bus
Rochester
Downtown Greyhound Station
Fastest
Bus
Rochester
537-517 W. Jackson Blvd
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Rochester
Chicago 95Th & Dan Ryan
No tags
Next departures for Rochester to Chicago on November 22
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Rochester
Chicago 95Th & Dan Ryan
Cheapest
Bus
Rochester
Downtown Greyhound Station
Fastest
FlixBus + Greyhound Lines, Inc.
Bus
Rochester
Downtown Greyhound Station
No tags
Bus
Rochester
537-517 W. Jackson Blvd
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Rochester
Chicago 95Th & Dan Ryan
No tags
Next departures for Rochester to Chicago on November 23
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Rochester
Chicago 95Th & Dan Ryan
Cheapest
Bus
Rochester
Downtown Greyhound Station
Fastest
Bus
Rochester
537-517 W. Jackson Blvd
No tags
Next departures for Rochester to Chicago on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Rochester
Chicago 95Th & Dan Ryan
Cheapest
Bus
Rochester
Downtown Greyhound Station
Fastest
Bus
Rochester
537-517 W. Jackson Blvd
No tags
Next departures for Rochester to Chicago on November 25
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Rochester
Chicago 95Th & Dan Ryan
Cheapest
Bus
Rochester
Downtown Greyhound Station
Fastest
Bus
Rochester
537-517 W. Jackson Blvd
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Rochester
Chicago 95Th & Dan Ryan
No tags
Next departures for Rochester to Chicago on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Rochester
Chicago 95Th & Dan Ryan
Cheapest
Bus
Rochester
Downtown Greyhound Station
Fastest
Bus
Rochester
537-517 W. Jackson Blvd
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Rochester
Chicago 95Th & Dan Ryan
No tags
Next departures for Rochester to Chicago on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Rochester
Chicago 95Th & Dan Ryan
Cheapest
Bus
Rochester
Downtown Greyhound Station
Fastest
Bus
Rochester
537-517 W. Jackson Blvd
No tags
Last refresh of the prices: Yesterday at 10:59 PM EST.
Compare 2 ways to go from Rochester to Chicago
We recommend taking the train
Among the sustainable travel choices, the train stands out as the good way to reach Chicago. The journey takes about 11 hours 43 minutes and with fares starting at just $56, it presents an excellent value for a comfortable ride.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Trailways is a network of over 70 bus companies that focus on providing quality bus rides at affordable prices all over the US since 1936. Among the most famous affiliates are Trailways of New York, Pine Hill Trailways, Adirondack Trailways and Burlington Trailways. Trailways buses have WiFi, power outlets, bathrooms, air conditioning, overhead lighting, and reclinable seats with footrests. You can find two different types of Trailway fares: saver and flexible. Saver tickets are non-refundable, while flexible tickets are fully reimbursed up to one hour before travel time. If you're traveling with them, don't forget to print your boarding pass and show a valid photo ID to board the bus.
Frequently asked questions about traveling from Rochester, NY, US to Chicago by bus
How far is Rochester from Chicago?
Rochester and Chicago are 519 miles (836 km) apart.
What are the departure and arrival stations when taking the bus from Rochester to Chicago?
Most of the buses traveling from Rochester to Chicago leave from Bus Station and arrive at Downtown Greyhound Station. These are the most popular departure and arrival locations on this route, but you can also find other options that could better fit your plans.
What are the best sights and things to do in Chicago?
Once in Chicago, you can start exploring the city and discover its surroundings. The top sights and things to do are Architectural River Cruise, Lincoln Park Conservatory, Chicago Shakespeare Theater on Navy Pier, Navy Pier and Museum of Science and Industry.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/18
$83
11/19
$83
Today
$83
11/21
$83
11/22
$93
11/23
$83
11/24
$83
11/25
$128
The cheapest trip from Rochester, NY, US to Chicago was searched and found on Nov 18, 2025 with a price of $83
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rochester, NY, US to Chicago, as early as possible.
You can expect to pay from $83 to $280 for a bus ticket from Rochester, NY, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $83 which is on 2025-11-21.