What is the travel distance from Santa Cruz to Santiago?

About 95 miles (153 km) separate Santa Cruz and Santiago.

What are the departure and arrival stations when taking the bus from Santa Cruz to Santiago?

The majority of buses traveling from Santa Cruz to Santiago start their journey at Terminal Santa Cruz and wind up at Terminal Sur. These are the main pick-up and drop-off locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.

What are the best sights and things to do in Santiago?

Once in Santiago, you can start exploring the city and discover its surroundings. The top sights and things to do are El Biógrafo, Casablanca Valley Wine Tasting, Museo Nacional de Bellas Artes, Museo de la Memoria y los Derechos Humanos and La Chascona House.

Bus Santa Cruz to Santiago from $7 | Refundable Tickets

Next bus departures

Next departures for Santa Cruz to Santiago on November 18
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	6:50am	Terminal de Buses Santa Cruz	2h 24m	9:14am	San Bernardo, Santiago (Cruce Colon)	Cheapest
Bus	7:00am	Terminal Santa Cruz	2h	9:00am	Terminal Sur	Fastest
Bus	12:20pm	Terminal Santa Cruz	3h	3:20pm	Terminal Sur	No tags
Bus	7:10pm	Terminal Santa Cruz	3h 15m	10:25pm	Terminal Sur	No tags
Bus	7:30am	Terminal de Buses Santa Cruz	2h 24m	9:54am	San Bernardo, Santiago (Cruce Colon)	No tags

Next departures for Santa Cruz to Santiago on November 20
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	5:00am	Terminal de Buses Santa Cruz	2h 24m	7:24am	San Bernardo, Santiago (Cruce Colon)	Cheapest
Bus	7:00am	Terminal Santa Cruz	2h	9:00am	Terminal Sur	Fastest
Bus	5:20pm	Terminal Santa Cruz	3h	8:20pm	Terminal Sur	No tags
Bus	5:10pm	Terminal Santa Cruz	3h 15m	8:25pm	Terminal Sur	No tags
Bus	5:50am	Terminal de Buses Santa Cruz	2h 24m	8:14am	San Bernardo, Santiago (Cruce Colon)	No tags

Next departures for Santa Cruz to Santiago on November 21
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	5:00am	Terminal de Buses Santa Cruz	2h 24m	7:24am	San Bernardo, Santiago (Cruce Colon)	Cheapest
Bus	7:00am	Terminal Santa Cruz	2h	9:00am	Terminal Sur	Fastest
Bus	8:30am	Terminal Santa Cruz	3h	11:30am	Terminal Sur	No tags
Bus	2:10pm	Terminal Santa Cruz	3h 15m	5:25pm	Terminal Sur	No tags
Bus	5:50am	Terminal de Buses Santa Cruz	2h 24m	8:14am	San Bernardo, Santiago (Cruce Colon)	No tags

Next departures for Santa Cruz to Santiago on November 22
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	5:00am	Terminal de Buses Santa Cruz	2h 24m	7:24am	San Bernardo, Santiago (Cruce Colon)	Cheapest
Bus	7:00am	Terminal Santa Cruz	2h	9:00am	Terminal Sur	Fastest
Bus	8:30am	Terminal Santa Cruz	3h	11:30am	Terminal Sur	No tags
Bus	2:10pm	Terminal Santa Cruz	3h 15m	5:25pm	Terminal Sur	No tags
Bus	5:50am	Terminal de Buses Santa Cruz	2h 24m	8:14am	San Bernardo, Santiago (Cruce Colon)	No tags

Last refresh of the prices: Yesterday at 10:44 PM -03.

Get from Santa Cruz to Santiago

This route is served by bus only

The journey takes about 2 hours 44 minutes and with fares starting at just $6, it presents an excellent value for a comfortable ride.

37bus per day

2h 44mAverage Duration

91 milesDistance

4kgCO₂ emissions

Compare bus companies

Buses Andimar

4/554 reviews

Staff4.4

Timeliness4.6

Cleanliness4.6

Wifi1.2

Users have reported a positive experience with the service, highlighting on-time departures and comfortable seating that made for an enjoyable trip. Although there were some initial challenges with online booking, assistance from staff was appreciated in resolving these issues effectively.

Andimar Santa Cruz Santiago recent customer reviews

It was fine. Very busy.

Paul O.

August 25, 2025

On time departure. Comfortable seats. Enjoyable trip.

Mary H.

August 18, 2025

Had issues booking online but had a person really help me on the other end.

Monica Lee D.

March 19, 2024

buses TranSantin

4/5278 reviews

Staff4.9

Timeliness4.3

Cleanliness4.5

Wifi1.8

Buses Jet Sur

3.5/577 reviews

Staff4.4

Timeliness4.4

Cleanliness3.9

Wifi0.7

CL bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Where are the popular stops in Santa Cruz and Santiago?

Stops in Santa Cruz

A - Terminal Santa Cruz

Stops in Santiago

A - Terminal Sur

B - San Borja

C - Terminal Los Héroes

D - Terminal ETM

E - Pajaritos

F - Santiago

Frequently asked questions about traveling from Santa Cruz, CL to Santiago, CL by bus

What is the travel distance from Santa Cruz to Santiago?
What are the departure and arrival stations when taking the bus from Santa Cruz to Santiago?
What are the best sights and things to do in Santiago?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/16

$9

11/17

$7

Today

$7

11/19

$7

11/20

$7

11/21

$7

11/22

$7

11/23

$7

The cheapest trip from Santa Cruz, CL to Santiago, CL was searched and found on Nov 19, 2025 with a price of $7

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Cruz, CL to Santiago, CL, as early as possible.

You can expect to pay from $7 to $111 for a bus ticket from Santa Cruz, CL to Santiago, CL based on the last 2 days. You can expect to find the cheapest price for the trip at $7 which is on 2025-11-19.

Usually Buses Jet Sur will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.