Bus Tickets from Des Moines to St Louis

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SatMay 24
SunMay 25
MonMay 26
TueMay 27
WedMay 28
from US$101
ThuMay 29
FriMay 30
SatMay 31

Cheap buses leaving Wednesday

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: May 28 at
    Departure city: Des Moines
    Departure location: Des Moines (Subway)
    Arrival time: May 28 at
    Destination city: St Louis
    Destination location: Gateway Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

Last refresh of the prices: Last Tuesday at 9:57 PM CDT.

Prices and availability are subject to change.

Accepted payments

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Bus Des Moines to St Louis: Trip Overview

Average Ticket PriceUS$109
Average Bus Trip Duration17h 55m
Number of daily buses1
Earliest bus departure5:30am
Distance439 km
Latest bus departure11:15pm

Des Moines to St Louis Bus

Busbud helps you find a bus from Des Moines to St Louis. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Des Moines to St Louis.

Whether it is cheap bus tickets or more luxurious buses going to St Louis from Des Moines, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Des Moines - St Louis

  1. How long does it take to get to St Louis from Des Moines by bus?

    The typical travel time from Des Moines to St Louis by bus is around 17h 55m. For the shortest travel time, select the fastest bus available, which will take you to St Louis in about 8h 20m.

  2. What is the distance between Des Moines and St Louis?

    The distance covered from Des Moines to St Louis is 441 km (273 miles).

  3. What are the departure and arrival locations for buses traveling from Des Moines to St Louis?

    Buses traveling this route start their trip at Jefferson/Trailways Depot, in Des Moines, and end it at Gateway Station, in St Louis.

  4. What is the cheapest way to go from Des Moines to St Louis?

    The least expensive way to go from Des Moines to St Louis would be going by bus. Starting at US$87, this bus is the most cost-effective option for your journey.

  5. How much is the bus from Des Moines to St Louis?

    The bus fare from Des Moines to St Louis is approximately US$109.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05-20
No data
05-21
No data
Today
US$79
05-23
US$92
05-24
US$101
05-25
No data
05-26
US$83
05-27
No data
busbud logoThe cheapest trip from Des Moines to St Louis was searched and found on May 22, 2025 with a price of US$79

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to St Louis, as early as possible.

You can expect to pay from US$79 to US$101 for a bus ticket from Des Moines to St Louis based on the last 2 days. You can expect to find the cheapest price for the trip at US$83 which is on 2025-05-26.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Des Moines and St Louis!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Des Moines to St Louis.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Des Moines to St Louis.

Tune out to the fine sounds of your best music playlist on your bus trip from Des Moines to St Louis while indulging in miles on end of beautiful scenic views.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Will you be returning to Des Moines by bus?

Bus from Des Moines to St Louis

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