Bus Tickets from Louisville to San Diego, CA, US

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Previously seen trips

One passenger / one way

  • Departure time: September 2 at
    Departure city: Louisville
    Departure location: Louisville, KY
    Arrival time: September 5 at
    Destination city: San Diego
    Destination location: 5716 Hardy Ave
    Operated by: FlixBus + Greyhound
    FlixBus + Greyhound
    Vehicle: BusDuration:
  • Departure time: September 2 at
    Departure city: Louisville
    Departure location: Louisville, KY
    Arrival time: September 5 at
    Destination city: San Diego
    Destination location: Greyhound Bus Stop
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: September 2 at
    Departure city: Louisville
    Departure location: Louisville, KY
    Arrival time: September 5 at
    Destination city: San Diego
    Destination location: Downtown SD (Seaport)
    Operated by: FlixBus + Greyhound
    FlixBus + Greyhound
    Vehicle: BusDuration:
  • Departure time: September 2 at
    Departure city: Louisville
    Departure location: Louisville, KY
    Arrival time: September 5 at
    Destination city: San Diego
    Destination location: UCSD Health La Jolla Station
    Operated by: FlixBus + Greyhound
    FlixBus + Greyhound
    Vehicle: BusDuration:
  • Departure time: September 2 at
    Departure city: Louisville
    Departure location: Louisville, KY
    Arrival time: September 5 at
    Destination city: San Diego
    Destination location: San Diego (Old Town-FlixBus)
    Operated by: FlixBus + Greyhound
    FlixBus + Greyhound
    Vehicle: BusDuration:

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Bus Louisville to San Diego, CA, US: Trip Overview

Average ticket price$222
Average bus trip duration2d 9h
Number of daily buses14
Earliest bus departure3:35am
Distance1795 miles (2895 km)
Latest bus departure10:55pm

Louisville to San Diego Bus

Busbud helps you find a bus from Louisville to San Diego. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Louisville to San Diego.

Discover how much the bus trip from Louisville to San Diego will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip Louisville - San Diego, CA, US

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/24
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08/25
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Today
$191
08/27
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08/28
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08/29
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08/30
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08/31
$173
busbud logoThe cheapest trip from Louisville to San Diego, CA, US was searched and found on Aug 31, 2025 with a price of $173

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Louisville to San Diego, CA, US, as early as possible.

You can expect to pay from $173 to $203 for a bus ticket from Louisville to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $173 which is on 2025-08-31.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Louisville and San Diego!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Louisville to San Diego.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Louisville to San Diego will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from Louisville to San Diego, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Louisville by bus?

Bus from San Diego, CA, US to Louisville

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