Find the cheapest bus tickets from St Louis, MO to Chicago, IL

Easily search and book your next trip with Busbud

Cheap buses leaving today

One passenger / one way

7:20 PM1:25 AM
$26
St Louis - Gateway StationChicago - 95th & Dan Ryan CTA
7:20 PM
St Louis - Gateway Station
1:25 AM
Chicago - 95th & Dan Ryan CTA
Greyhound
$26
2:00 PM8:00 PM
$27
St Louis - Gateway StationChicago - Downtown Greyhound Station
2:00 PM
St Louis - Gateway Station
8:00 PM
Chicago - Downtown Greyhound Station
Greyhound
$27
7:20 PM1:45 AM
$27
St Louis - Gateway StationChicago - Downtown Greyhound Station
7:20 PM
St Louis - Gateway Station
1:45 AM
Chicago - Downtown Greyhound Station
Greyhound
$27
11:55 PM8:35 AM
$29
St Louis - Gateway StationChicago - Downtown Greyhound Station
11:55 PM
St Louis - Gateway Station
8:35 AM
Chicago - Downtown Greyhound Station
Greyhound
$29
2:00 PM9:20 PM
$30
St Louis - Gateway StationChicago - 95th & Dan Ryan CTA
2:00 PM
St Louis - Gateway Station
9:20 PM
Chicago - 95th & Dan Ryan CTA
Greyhound
$30
7:20 PM1:25 AM
$26
St Louis - Gateway StationChicago - 95th & Dan Ryan CTA
7:20 PM
St Louis - Gateway Station
1:25 AM
Chicago - 95th & Dan Ryan CTA
Greyhound
$26

Cheap buses leaving tomorrow

One passenger / one way

7:20 PM1:25 AM
$21
St Louis - Gateway StationChicago - 95th & Dan Ryan CTA
7:20 PM
St Louis - Gateway Station
1:25 AM
Chicago - 95th & Dan Ryan CTA
Greyhound
$21
7:20 PM6:55 AM
$21
St Louis - Gateway StationChicago - Cumberland CTA
7:20 PM
St Louis - Gateway Station
6:55 AM
Chicago - Cumberland CTA
Greyhound
$21
8:30 AM3:00 PM
$22
St Louis - Gateway StationChicago - 95th & Dan Ryan CTA
8:30 AM
St Louis - Gateway Station
3:00 PM
Chicago - 95th & Dan Ryan CTA
Greyhound
$22
7:20 PM1:45 AM
$22
St Louis - Gateway StationChicago - Downtown Greyhound Station
7:20 PM
St Louis - Gateway Station
1:45 AM
Chicago - Downtown Greyhound Station
Greyhound
$22
4:00 AM4:20 PM
$22
St Louis - Gateway StationChicago - Cumberland CTA
4:00 AM
St Louis - Gateway Station
4:20 PM
Chicago - Cumberland CTA
Greyhound
$22
7:20 PM1:25 AM
$21
St Louis - Gateway StationChicago - 95th & Dan Ryan CTA
7:20 PM
St Louis - Gateway Station
1:25 AM
Chicago - 95th & Dan Ryan CTA
Greyhound
$21

Cheap buses leaving Tuesday

One passenger / one way

4:00 AM4:20 PM
$19
St Louis - Gateway StationChicago - Cumberland CTA
4:00 AM
St Louis - Gateway Station
4:20 PM
Chicago - Cumberland CTA
Greyhound
$19
7:20 PM1:25 AM
$20
St Louis - Gateway StationChicago - 95th & Dan Ryan CTA
7:20 PM
St Louis - Gateway Station
1:25 AM
Chicago - 95th & Dan Ryan CTA
Greyhound
$20
8:30 AM3:00 PM
$20
St Louis - Gateway StationChicago - 95th & Dan Ryan CTA
8:30 AM
St Louis - Gateway Station
3:00 PM
Chicago - 95th & Dan Ryan CTA
Greyhound
$20
4:00 AM9:45 AM
$20
St Louis - Gateway StationChicago - 95th & Dan Ryan CTA
4:00 AM
St Louis - Gateway Station
9:45 AM
Chicago - 95th & Dan Ryan CTA
Greyhound
$20
4:30 AM1:40 PM
$20
St Louis - Gateway StationChicago - Downtown Greyhound Station
4:30 AM
St Louis - Gateway Station
1:40 PM
Chicago - Downtown Greyhound Station
Greyhound
$20
4:00 AM4:20 PM
$19
St Louis - Gateway StationChicago - Cumberland CTA
4:00 AM
St Louis - Gateway Station
4:20 PM
Chicago - Cumberland CTA
Greyhound
$19

Cheap buses leaving Wednesday

One passenger / one way

4:00 AM2:15 PM
$17
St Louis - Gateway StationChicago - Union Station
4:00 AM
St Louis - Gateway Station
2:15 PM
Chicago - Union Station
Greyhound
$17
4:00 AM4:20 PM
$17
St Louis - Gateway StationChicago - Cumberland CTA
4:00 AM
St Louis - Gateway Station
4:20 PM
Chicago - Cumberland CTA
Greyhound
$17
2:00 PM9:45 PM
$17
St Louis - Gateway StationChicago - Union Station
2:00 PM
St Louis - Gateway Station
9:45 PM
Chicago - Union Station
Greyhound
$17
4:00 AM9:45 AM
$17
St Louis - Gateway StationChicago - 95th & Dan Ryan CTA
4:00 AM
St Louis - Gateway Station
9:45 AM
Chicago - 95th & Dan Ryan CTA
Greyhound
$17
8:30 AM5:45 PM
$17
St Louis - Gateway StationChicago - Union Station
8:30 AM
St Louis - Gateway Station
5:45 PM
Chicago - Union Station
Greyhound
$17
4:00 AM2:15 PM
$17
St Louis - Gateway StationChicago - Union Station
4:00 AM
St Louis - Gateway Station
2:15 PM
Chicago - Union Station
Greyhound
$17

Cheap buses leaving Thursday

One passenger / one way

8:30 AM4:20 PM
$17
St Louis - Gateway StationChicago - Cumberland CTA
8:30 AM
St Louis - Gateway Station
4:20 PM
Chicago - Cumberland CTA
Greyhound
$17
7:20 PM6:55 AM
$17
St Louis - Gateway StationChicago - Cumberland CTA
7:20 PM
St Louis - Gateway Station
6:55 AM
Chicago - Cumberland CTA
Greyhound
$17
4:00 AM9:45 AM
$17
St Louis - Gateway StationChicago - 95th & Dan Ryan CTA
4:00 AM
St Louis - Gateway Station
9:45 AM
Chicago - 95th & Dan Ryan CTA
Greyhound
$17
8:30 AM3:00 PM
$17
St Louis - Gateway StationChicago - 95th & Dan Ryan CTA
8:30 AM
St Louis - Gateway Station
3:00 PM
Chicago - 95th & Dan Ryan CTA
Greyhound
$17
2:00 PM9:20 PM
$17
St Louis - Gateway StationChicago - 95th & Dan Ryan CTA
2:00 PM
St Louis - Gateway Station
9:20 PM
Chicago - 95th & Dan Ryan CTA
Greyhound
$17
8:30 AM4:20 PM
$17
St Louis - Gateway StationChicago - Cumberland CTA
8:30 AM
St Louis - Gateway Station
4:20 PM
Chicago - Cumberland CTA
Greyhound
$17

Cheap buses leaving Friday

One passenger / one way

4:00 AM9:45 AM
$24
St Louis - Gateway StationChicago - 95th & Dan Ryan CTA
4:00 AM
St Louis - Gateway Station
9:45 AM
Chicago - 95th & Dan Ryan CTA
Greyhound
$24
2:00 PM9:20 PM
$24
St Louis - Gateway StationChicago - 95th & Dan Ryan CTA
2:00 PM
St Louis - Gateway Station
9:20 PM
Chicago - 95th & Dan Ryan CTA
Greyhound
$24
7:20 PM1:25 AM
$24
St Louis - Gateway StationChicago - 95th & Dan Ryan CTA
7:20 PM
St Louis - Gateway Station
1:25 AM
Chicago - 95th & Dan Ryan CTA
Greyhound
$24
8:30 AM3:00 PM
$26
St Louis - Gateway StationChicago - 95th & Dan Ryan CTA
8:30 AM
St Louis - Gateway Station
3:00 PM
Chicago - 95th & Dan Ryan CTA
Greyhound
$26
10:00 PM10:10 AM
$28
St Louis - STL AirportChicago - Downtown Greyhound Station
10:00 PM
St Louis - STL Airport
10:10 AM
Chicago - Downtown Greyhound Station
Greyhound
$28
4:00 AM9:45 AM
$24
St Louis - Gateway StationChicago - 95th & Dan Ryan CTA
4:00 AM
St Louis - Gateway Station
9:45 AM
Chicago - 95th & Dan Ryan CTA
Greyhound
$24

Bus St Louis to Chicago: Trip Overview

15
Daily Buses
12:15 AM - 11:55 PM
Earliest and Latest Bus Departures
$23
Average Ticket Price
Average Bus Trip Duration

Trip Reviews for St Louis - Chicago

3.0 out of 5 stars

User reviews from travelers who booked a bus ticket from St Louis to Chicago

Ratings and Reviews (14)


Osiris B.July 18, 2019 | 

All good

Shelia S.July 18, 2019 | 

My first time from along time to many stops little confusing if we were close or what time we really will be in Chicago in all Ok!

Laura M.October 18, 2018 | 

Very professional and courteous. Actually, quite a bit more professional and less stressful than air travel presently. Pleasantly surprised!

Alfio G.September 2, 2018 | 

Don't go Grayhound the don't do maintenance on their busses caught but A at 1030am bus breaks down replacement bus arrives at 9.00pm go Megabus

Kelsie M.August 17, 2018 | 

Late, terrible driving

Chauramma C.August 14, 2018 | 

I had asked for an exchange of date and I never got response. I had made the request on the phone.

Oscar K.June 21, 2018 | 

Very bad service very late and not clear what was going on on the trip? Delayed both trips.

Sukanya C.June 8, 2018 | 

It was a very bad experience and I would never travel on grethound again...

Larisa M.May 5, 2018 | 

8.5 hours trip

Kurmanzhan B.July 28, 2017 | 

My way from St Louis to Chicago took 10 hours instead of 6.55 . It was horrible trip I've ever had!!!!

Parichart W.June 24, 2017 | 

The bus is clean. Staff is polite. However, passengers are more than the seats, some passengers have to wait for the next bus. This causes a delay of the trip.

Veronika P.April 24, 2017 | 

Great driver

Lisa X.March 30, 2017 | 

The driver was very nice, he made sure I was on the bus when we stopped at a convenience store!

Trevor R.August 13, 2016 | 

Horrible. The staff was friendly. But the bus got in TWO HOURS LATE

Bus Companies on This Route

St Louis to Chicago Buses

Busbud helps you find a bus from St Louis to Chicago. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from St Louis to Chicago.

Whether it is cheap bus tickets or more luxurious buses going to Chicago from St Louis, we help you find what you're looking for based on how much of a budget you have.

Bus Companies

St Louis to Chicago bus tickets are provided by Greyhound.

Stations & Stops

For a bus leaving from St Louis, the trip starts at Gateway Station, San Luis, Misuri, STL Airport or St Louis, MO.

In Chicago, your bus travel ends at Downtown Greyhound Station, 95th & Dan Ryan CTA, Turimex California Ave, Union Station, Cumberland CTA, Tornado Bus S Kedzie Ave, Chicago, IL, ORD Airport, ORD Airport or Polk St & Canal St.

Information on this bus route

Daily Buses15
Earliest and Latest Bus Departures12:15 AM - 11:55 PM
Minimum Price$16
Average Ticket Price$23
Minimum Trip Duration
Average Bus Trip Duration
Bus Companies on This RouteGreyhound US

St Louis to Chicago Route Map

St Louis to Chicago Route Map

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between St Louis and Chicago!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from St Louis to Chicago.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St Louis to Chicago.

Make a music playlist for your bus ride from St Louis to Chicago, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to St Louis by bus?

If you are looking for the return bus journey, check out buses from Chicago to St Louis.

Popular Buses Connecting St Louis

Popular Buses Connecting Chicago

Popular routes in this country

About Busbud

The Best Way To Book Bus Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS, National Express and many others so you can buy tickets without a worry.

Why Busbud?

  • Your trip, your priorities
  • Global coverage
  • 24/7 support