What is the travel distance from Knoxville to Greenville?

About 115 miles (186 km) separate Knoxville and Greenville.

What are the departure and arrival stations when taking the bus from Knoxville to Greenville?

The majority of buses traveling from Knoxville to Greenville start their journey at 100 Kirkwood St and wind up at Guadalajara Supermarket Bus Stop. These are the main pick-up and drop-off locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.

Bus Knoxville to Greenville from $62 | Refundable Tickets

Previously seen trips

Next departures for Knoxville to Greenville on November 9
Operated by	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	6:45pm	Knoxville Bus Station	12h 50m	7:35am	1116 Woodruff Rd	No tags
FlixBus + Greyhound	11:45pm	Knoxville Bus Station	12h 15m	12:00pm	1116 Woodruff Rd	No tags
	7:05pm	Knoxville Bus Station	12h 30m	7:35am	1116 Woodruff Rd	No tags
	7:05pm	Knoxville Bus Station	12h 30m	7:35am	1116 Woodruff Rd	No tags
FlixBus + Greyhound	6:45pm	Knoxville Bus Station	15h 15m	10:00am	1116 Woodruff Rd	No tags

Get from Knoxville to Greenville

This route is served by bus only

The journey takes about 11 hours 40 minutes and with fares starting at just $62, it presents an excellent value for a comfortable ride.

1bus per day

11h 40mAverage Duration

120 milesDistance

5kgCO₂ emissions

Compare bus companies

Greyhound

3.5/587,359 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Where are the popular stops in Knoxville and Greenville?

Stops in Knoxville

A - 100 Kirkwood St

Stops in Greenville

A - Guadalajara Supermarket Bus Stop

B - Greenville Bus Station

Frequently asked questions about traveling from Knoxville, TN to Greenville, SC by bus

What is the travel distance from Knoxville to Greenville?
What are the departure and arrival stations when taking the bus from Knoxville to Greenville?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/07

No data

11/08

$104

Today

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11/10

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11/11

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11/12

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11/13

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11/14

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The cheapest trip from Knoxville, TN to Greenville, SC was searched and found on Nov 8, 2025 with a price of $104

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Greenville, SC, as early as possible.

Top traveled bus routes

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