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- This trip is recommended because it is the: CheapestDeparture time: May 29 atDeparture city: San DiegoDeparture location: Greyhound Bus StopArrival time: June 1 atDestination city: GreenvilleDestination location: 1116 Woodruff RdOperated by: Greyhound Lines, Inc.
Vehicle: BusDuration: - This trip is recommended because it is the: Fastest
Last refresh of the prices: Yesterday at 7:11 PM PDT.
Prices and availability are subject to change.
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Bus San Diego to Greenville: Trip Overview
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San Diego to Greenville Bus
With Busbud, comparing and booking tickets for a bus from San Diego to Greenville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
We make sure you can find a bus service from San Diego to Greenville from the most reliable bus companies operating this trip.
Whether it is cheap bus tickets or more luxurious buses going to Greenville from San Diego, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in San Diego and Greenville?
Frequently asked questions on the trip San Diego (CA), US - Greenville (SC)
How long does it take to get to Greenville from San Diego by bus?
The trip from San Diego to Greenville will take on average 2d 11h. For the shortest travel time, select the fastest bus available, which will take you to Greenville in about 2d 7h.
What is the distance between San Diego and Greenville?
The distance between San Diego and Greenville is around 3210 km (1990 miles).
What are the departure and arrival locations for buses traveling from San Diego to Greenville?
Buses traveling this route start their trip at Mission Valley Sheraton, in San Diego, and end it at Guadalajara Supermarket Bus Stop, in Greenville.
What is the cheapest way to travel from San Diego to Greenville?
The least expensive way to go from San Diego to Greenville would be going by bus. The ticket price for this bus starts at US$165, making this your best choice for this trip.
How much is the bus from San Diego to Greenville?
Taking the bus from San Diego to Greenville costs on average US$189.
Is it possible to travel by overnight bus from San Diego to Greenville?
Yes! Catch buses leaving from San Diego until 7:35pm and reaching Greenville on the following day.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Diego to Greenville was searched and found on May 29, 2025 with a price of US$298To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego to Greenville, as early as possible.
You can expect to pay from US$298 to US$298 for a bus ticket from San Diego to Greenville based on the last 2 days. You can expect to find the cheapest price for the trip at US$298 which is on 2025-05-29.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while travelling from San Diego to Greenville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from San Diego to Greenville, get comfy and count the stars.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from San Diego to Greenville.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from San Diego to Greenville.
Did you know?
Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
Top travelled bus routes
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Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.
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