Bus Tickets from Knoxville, TN to Greenville, SC

Previously seen trips

Next departures for Knoxville to Greenville on October 13
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound
Knoxville Bus Station
1116 Woodruff RdNo tags
FlixBus + Greyhound
Knoxville Bus Station
1116 Woodruff RdNo tags
Greyhound
Knoxville Bus Station
1116 Woodruff RdNo tags
Greyhound
Knoxville Bus Station
1116 Woodruff RdNo tags
FlixBus + Greyhound
Knoxville Bus Station
1116 Woodruff RdNo tags

Accepted payments

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Bus Knoxville, TN to Greenville, SC: Trip Overview

Average Ticket PriceUS$72
Average Bus Trip Duration11h 40m
Number of daily buses1
Earliest bus departure7:25pm
Distance193 km

Knoxville to Greenville Bus

With Busbud, comparing and booking tickets for a bus from Knoxville to Greenville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Knoxville to Greenville.

Whether it is cheap bus tickets or more luxurious buses going to Greenville from Knoxville, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Knoxville, TN - Greenville, SC

  1. What is the travel distance from Knoxville to Greenville?

    The distance covered from Knoxville to Greenville is 186 km (115 miles).

  2. What are the departure and arrival locations for buses traveling from Knoxville to Greenville?

    Buses traveling this route start their trip at 100 Kirkwood St, in Knoxville, and end it at Guadalajara Supermarket Bus Stop, in Greenville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
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10-12
US$55
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busbud logoThe cheapest trip from Knoxville, TN to Greenville, SC was searched and found on Oct 12, 2025 with a price of US$55

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Greenville, SC, as early as possible.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Knoxville to Greenville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Knoxville to Greenville.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Knoxville to Greenville.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Knoxville to Greenville.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Will you be returning to Knoxville, TN by bus?

Bus from Greenville, SC to Knoxville, TN

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