Bus Tickets from St. Louis to Santa Ana, US

Previously seen trips

Next departures for St. Louis to Santa Ana on November 5
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound
    		Gateway Station
    		Santa Ana Bus StationNo tags
    Greyhound
      		Gateway Station
      		Santa Ana Bus StationNo tags
      Greyhound
        		Saint Louis (Lambert Field)
        		Santa Ana Bus StationNo tags
        FlixBus + Greyhound
          		Saint Louis (Lambert Field)
          		UC Irvine (Crawford Hall)No tags
          Greyhound + FlixBus
            		Saint Louis (Lambert Field)
            		Santa Ana Bus StationNo tags

            Accepted payments

            • Visa
            • MasterCard
            • American Express
            • China Union Pay
            • Diners Club Canada
            • Discover Click to Pay
            • JCB payment
            • Klarna (Pay over time)
            • Google Pay

            Get from St. Louis to Santa Ana

            This route is served by bus only

            The journey takes about 1 day, 20 hours 30 minutes, and with fares starting at just $201, it presents an excellent value for a comfortable ride.

            2bus per day
            1d 20hAverage Duration
            2530 kmDistance
            63kgCO₂ emissions

            Bus St. Louis to Santa Ana, US: Trip Overview

            Average Ticket Price$254
            Average Bus Trip Duration1d 20h
            Number of daily buses2
            Earliest bus departure12:55am
            Distance2530 km
            Latest bus departure4:30pm

            St. Louis to Santa Ana Bus

            With Busbud, comparing and booking tickets for a bus from St. Louis to Santa Ana is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

            Bus service from St. Louis to Santa Ana will be provided by the most trusted bus companies.

            Whether it is cheap bus tickets or more luxurious buses going to Santa Ana from St. Louis, we help you find what you're looking for based on how much of a budget you have.

            Frequently asked questions on the trip St. Louis - Santa Ana, US

            1. How far is St. Louis from Santa Ana?

              The distance between St. Louis and Santa Ana is approximately 2535 km (1572 miles).

            2. What are the departure and arrival locations for buses traveling from St. Louis to Santa Ana?

              Buses departing from Gateway Station in St. Louis will take you to Santa Ana Greyhound Bus Station in Santa Ana.

            Find cheapest prices for buses

            Price is for a one-way ticket for one passenger and based on past searches.

            Best price found
            11-03
            No data
            11-04
            $388
            Today
            $297
            11-06
            No data
            11-07
            $324
            11-08
            No data
            11-09
            $335
            11-10
            $306
            busbud logoThe cheapest trip from St. Louis to Santa Ana, US was searched and found on Nov 5, 2025 with a price of $297

            To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Santa Ana, US, as early as possible.

            You can expect to pay from $297 to $388 for a bus ticket from St. Louis to Santa Ana, US based on the last 2 days. You can expect to find the cheapest price for the trip at $306 which is on 2025-11-10.

            About Bus Travel

            Bus Travel Tips

            Meet and talk to locals at the bus stations while travelling from St. Louis to Santa Ana.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

            Much more than a mere vehicle taking you from St. Louis to Santa Ana, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

            Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St. Louis to Santa Ana.

            Tune out to the fine sounds of your best music playlist on your bus trip from St. Louis to Santa Ana while indulging in miles on end of beautiful scenic views.

            Did you know?

            One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

            The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

            9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

            Will you be returning to St. Louis by bus?

            Bus from Santa Ana, US to St. Louis

            Why choose Busbud?

            The Best Way To Book Bus and Train Tickets

            Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

            People from around the world trust Busbud

            ‌

            Popular Buses Connecting St. Louis

            Buses Leaving from St. Louis

            Buses Going to St. Louis

            Popular Buses Connecting Santa Ana

            Buses Leaving from Santa Ana

            Buses Going to Santa Ana