Bus Tickets from St. Louis to Santa Ana, US

Previously seen trips

Next departures for St. Louis to Santa Ana on November 5
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound
    		Gateway Station
    		Santa Ana Bus StationNo tags
    Greyhound
      		Gateway Station
      		Santa Ana Bus StationNo tags
      Greyhound
        		Saint Louis (Lambert Field)
        		Santa Ana Bus StationNo tags
        FlixBus + Greyhound
          		Saint Louis (Lambert Field)
          		UC Irvine (Crawford Hall)No tags
          Greyhound + FlixBus
            		Saint Louis (Lambert Field)
            		Santa Ana Bus StationNo tags

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            • China Union Pay
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            • JCB payment
            • Klarna (Pay over time)
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            Get from St. Louis to Santa Ana

            This route is served by bus only

            The journey takes about 1 day, 20 hours 30 minutes and with fares starting at just $139, it presents an excellent value for a comfortable ride.

            2bus per day
            1d 20hAverage Duration
            1569 milesDistance
            63kgCO₂ emissions

            Bus St. Louis to Santa Ana, US: Trip Overview

            Average ticket price$176
            Average bus trip duration1d 20h
            Number of daily buses2
            Earliest bus departure12:55am
            Distance1569 miles (2530 km)
            Latest bus departure4:30pm

            St. Louis to Santa Ana Bus

            With Busbud, comparing and booking tickets for a bus from St. Louis to Santa Ana is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

            Bus service from St. Louis to Santa Ana will be provided by the most trusted bus companies.

            Whether it is cheap bus tickets or more luxurious buses going to Santa Ana from St. Louis, we help you find what you're looking for based on how much of a budget you have.

            Frequently asked questions for your trip St. Louis - Santa Ana, US

            Find cheapest prices for buses

            Price is for a one-way ticket for one passenger and based on past searches.

            Best price found
            11/03
            No data
            11/04
            $268
            Today
            $205
            11/06
            No data
            11/07
            $224
            11/08
            No data
            11/09
            $231
            11/10
            $211
            busbud logoThe cheapest trip from St. Louis to Santa Ana, US was searched and found on Nov 5, 2025 with a price of $205

            To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Santa Ana, US, as early as possible.

            You can expect to pay from $205 to $268 for a bus ticket from St. Louis to Santa Ana, US based on the last 2 days. You can expect to find the cheapest price for the trip at $211 which is on 2025-11-10.

            About Bus Travel

            Bus Travel Tips

            Meet and talk to locals at the bus stations while traveling from St. Louis to Santa Ana.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

            Much more than a mere vehicle taking you from St. Louis to Santa Ana, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

            Buses are energy-efficient. Carrying a passenger over 100 kms by bus only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St. Louis to Santa Ana.

            Tune out to the fine sounds of your best music playlist on your bus trip from St. Louis to Santa Ana while indulging in miles on end of beautiful scenic views.

            Did you know?

            One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

            The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

            9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

            Will you be returning to St. Louis by bus?

            Bus from Santa Ana, US to St. Louis

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