Bus Tickets from San Francisco, US to St. Louis

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TodayAug 29
from US$185
TomorrowAug 30
from US$244
SunAug 31
MonSep 1
TueSep 2
WedSep 3
ThuSep 4
FriSep 5

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: August 30 at
    Departure city: San Francisco
    Departure location: 409 Townsend St, SF
    Arrival time: September 2 at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: August 30 at
    Departure city: San Francisco
    Departure location: San Francisco Bus Station
    Arrival time: September 1 at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 30 at
    Departure city: San Francisco
    Departure location: 409 Townsend St, SF
    Arrival time: September 1 at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 30 at
    Departure city: San Francisco
    Departure location: San Francisco Bus Station
    Arrival time: September 1 at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 30 at
    Departure city: San Francisco
    Departure location: 409 Townsend St, SF
    Arrival time: September 1 at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Bus San Francisco, US to St. Louis: Trip Overview

Average Ticket PriceUS$188
Average Bus Trip Duration2d 6h
Number of daily buses6
Earliest bus departure7:45am
Distance2800 km
Latest bus departure11:25pm

San Francisco to St. Louis Bus

With Busbud, comparing and booking tickets for a bus from San Francisco to St. Louis is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from San Francisco to St. Louis.

Discover how much the bus trip from San Francisco to St. Louis will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip San Francisco, US - St. Louis

  1. What is the travel distance from San Francisco to St. Louis?

    The distance covered from San Francisco to St. Louis is 2806 km (1740 miles).

  2. What are the departure and arrival locations for buses traveling from San Francisco to St. Louis?

    Buses traveling this route start their trip at Hyde/Beach (Fisherman's Wharf), in San Francisco, and end it at Gateway Station, in St. Louis.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-27
US$127
08-28
No data
Today
US$170
08-30
US$248
08-31
No data
09-01
No data
09-02
No data
09-03
No data
busbud logoThe cheapest trip from San Francisco, US to St. Louis was searched and found on Aug 27, 2025 with a price of US$127

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Francisco, US to St. Louis, as early as possible.

You can expect to pay from US$127 to US$315 for a bus ticket from San Francisco, US to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at US$248 which is on 2025-08-30.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from San Francisco to St. Louis.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from San Francisco to St. Louis.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from San Francisco to St. Louis will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from San Francisco to St. Louis.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to San Francisco, US by bus?

Bus from St. Louis to San Francisco, US

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