Bus Tickets from San Francisco, US to St. Louis

Next departures

Next departures for San Francisco to St. Louis on August 30
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
409 Townsend St, SF
Gateway StationCheapest
Greyhound Lines, Inc.
San Francisco Bus Station
Gateway StationFastest
FlixBus + Greyhound Lines, Inc.
409 Townsend St, SF
Gateway StationNo tags
Greyhound Lines, Inc.
San Francisco Bus Station
Gateway StationNo tags
FlixBus + Greyhound Lines, Inc.
409 Townsend St, SF
Gateway StationNo tags

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Bus San Francisco, US to St. Louis: Trip Overview

Average ticket price$185
Average bus trip duration2d 6h
Number of daily buses6
Earliest bus departure7:45am
Distance1736 miles (2800 km)
Latest bus departure11:25pm

San Francisco to St. Louis Bus

With Busbud, comparing and booking tickets for a bus from San Francisco to St. Louis is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from San Francisco to St. Louis.

Discover how much the bus trip from San Francisco to St. Louis will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip San Francisco, US - St. Louis

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/26
No data
08/27
$127
Today
No data
08/29
$170
08/30
$248
08/31
No data
09/01
No data
09/02
No data
busbud logoThe cheapest trip from San Francisco, US to St. Louis was searched and found on Aug 27, 2025 with a price of $127

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Francisco, US to St. Louis, as early as possible.

You can expect to pay from $127 to $315 for a bus ticket from San Francisco, US to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $170 which is on 2025-08-29.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from San Francisco to St. Louis.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from San Francisco to St. Louis.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from San Francisco to St. Louis will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from San Francisco to St. Louis.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to San Francisco, US by bus?

Bus from St. Louis to San Francisco, US

Why choose Busbud?

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