Bus Tickets from St Louis to San Francisco (CA), US

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TodayMay 25
TomorrowMay 26
from US$368
TueMay 27
WedMay 28
ThuMay 29
FriMay 30
SatMay 31
SunJun 1

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: May 26 at
    Departure city: St Louis
    Departure location: Gateway Station
    Arrival time: May 28 at
    Destination city: San Francisco
    Destination location: 409 Townsend St, SF
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: May 26 at
    Departure city: St Louis
    Departure location: Gateway Station
    Arrival time: May 28 at
    Destination city: San Francisco
    Destination location: San Francisco Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: May 26 at
    Departure city: St Louis
    Departure location: Gateway Station
    Arrival time: May 28 at
    Destination city: San Francisco
    Destination location: 409 Townsend St, SF
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: May 26 at
    Departure city: St Louis
    Departure location: Gateway Station
    Arrival time: May 28 at
    Destination city: San Francisco
    Destination location: San Francisco Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: May 26 at
    Departure city: St Louis
    Departure location: St Louis, MO
    Arrival time: May 28 at
    Destination city: San Francisco
    Destination location: 409 Townsend St, SF
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:

Last refresh of the prices: Yesterday at 9:48 PM CDT.

Prices and availability are subject to change.

Accepted payments

  • Visa
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  • American Express
  • China Union Pay
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  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from St Louis to San Francisco

Average PriceUS$141 - US$412Average Duration2d 1h
70kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Average PriceUS$148 - US$1,628Average Duration2d 12h
255kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from St Louis to San Francisco

Among the sustainable travel choices, the bus stands out as a good way to reach San Francisco. The journey takes about 2 days, 1 hour 5 minutes, and with fares starting at just US$141, it presents an excellent value for a comfortable ride.

6bus per day
2d 1hAverage Duration
US$141Cheapest ticket
70kgCO₂ emissions

Bus St Louis to San Francisco: Trip Overview

Average Ticket PriceUS$341
Average Bus Trip Duration2d 1h
Number of daily buses6
Earliest bus departure7:35am
Distance2800 km
Latest bus departure4:30pm

St Louis to San Francisco Bus

With Busbud, comparing and booking tickets for a bus from St Louis to San Francisco is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from St Louis to San Francisco from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses travelling from St Louis to San Francisco, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip St Louis - San Francisco (CA), US

  1. How long does it take to get to San Francisco from St Louis by bus?

    The bus ride from St Louis to San Francisco takes 2d 1h, on average. For the shortest travel time, select the fastest bus available, which will take you to San Francisco in about 1d 21h.

  2. What is the distance between St Louis and San Francisco?

    The distance between St Louis and San Francisco is approximately 2806 km (1740 miles).

  3. What are the departure and arrival locations for buses traveling from St Louis to San Francisco?

    Buses departing from Gateway Station in St Louis will take you to Hyde/Beach (Fisherman's Wharf) in San Francisco.

  4. What is the cheapest way to get from St Louis to San Francisco?

    The least expensive way to go from St Louis to San Francisco would be going by bus. The ticket price for this bus starts at US$141, making this your best choice for this trip.

  5. How much is the bus from St Louis to San Francisco?

    You can expect to pay around US$341 for the bus ride from St Louis to San Francisco.

  6. Is it possible to travel by overnight bus from St Louis to San Francisco?

    Yes! If you're heading from St Louis to San Francisco, you'll find buses departing until 4:30pm and arriving the next day.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05-23
No data
05-24
No data
Today
No data
05-26
US$362
05-27
No data
05-28
No data
05-29
No data
05-30
No data
busbud logoThe cheapest trip from St Louis to San Francisco was searched and found on May 26, 2025 with a price of US$362

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St Louis to San Francisco, as early as possible.

You can expect to pay from US$362 to US$372 for a bus ticket from St Louis to San Francisco based on the last 2 days. You can expect to find the cheapest price for the trip at US$362 which is on 2025-05-26.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from St Louis to San Francisco.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from St Louis to San Francisco, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from St Louis to San Francisco that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from St Louis to San Francisco.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Will you be returning to St Louis by bus?

Bus from St Louis to San Francisco

You can also go to San Francisco by train

Train from St Louis to San Francisco

Why choose Busbud?

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