Bus Tickets from Framingham, MA to St Louis, MO

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Compare 2 ways to go from Framingham to St Louis.

Average Price$170 - $194Average Duration1d 9h
41kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Average Price$286 - $1,063Average Duration1d 5h
149kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from Framingham to St Louis

Among the sustainable travel choices, the train stands out as the good way to reach St Louis. The journey takes about 1 day, 5 hours 42 minutes and with fares starting at just $286, it presents an excellent value for a comfortable ride.

2train per day
1d 5hAverage Duration
$286Cheapest ticket
149kgCO₂ emissions

Bus Framingham to St Louis: Trip Overview

Average ticket price$170
Average bus trip duration1d 9h
Number of daily buses1
Earliest bus departure2:45pm
Distance1015 miles (1637 km)

Framingham to St Louis Bus

Busbud helps you find a bus from Framingham to St Louis. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from Framingham to St Louis will be provided by the most trusted bus companies.

Discover how much the bus trip from Framingham to St Louis will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip Framingham - St Louis

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

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$184
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busbud logoThe cheapest trip from Framingham to St Louis was searched and found on May 10, 2025 with a price of $184

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Framingham to St Louis, as early as possible.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Framingham and St Louis!

Much more than a mere vehicle taking you from Framingham to St Louis, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Framingham to St Louis will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from Framingham to St Louis, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

What's the cheapest way to go from Framingham to St Louis?

busbud logoThe bus is the cheapest travel choice for this destination

You can also go to St Louis by train

Train from Framingham to St Louis

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