Most buses depart from South Station, Alewife Station (Cambridge), or other stops in the city. However, you can find most of the departures from South Station, which is the main bus station in Boston and a hub for various transportation methods, including long and short-distance buses and trains.
NYC is a big city, so it's no surprise that it has many bus stations. The city's main bus station is the Port Authority Bus Terminal, but there are also other bus stops located throughout different neighborhoods, including GW Bridge station and stops in Queens, Midtown, and many other addresses in the city.
Some bus companies go from Boston to NYC through inland roads, driving by Worcester (MA) and Hartford (CT), while other operators go through a more scenic route along the coast, traveling across Providence (RI).
The prices for this trip can vary considerably depending on which company you choose to travel with and how early you book your tickets. In general, Ourbus offers the best prices, with tickets starting at $19. If you book your tickets on the same day, they can cost you up to $116.
Most of the bus companies on this route offer amenities that include Wi-Fi, bathrooms, and USB plugs to charge your phone. However, some Busbud travelers report that internet services are not always reliable.
Some companies excel in customer service, while others may have more comfortable seating. For example, you may find more departure times offered by Greyhound, but Ourbus has a better reputation when it comes to customer service.
It's helpful to be aware that if your trip happens to coincide with rush hours, there's a possibility of encountering some traffic since you'll be heading towards one of the largest cities in the country.