Bus Knoxville to Louisville: Trip Overview
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Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Knoxville to Louisville Bus
Busbud helps you find a bus from Knoxville to Louisville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
We make sure you can find a bus service from Knoxville to Louisville from the most reliable bus companies operating this trip.
From cheap bus tickets to more luxurious buses traveling from Knoxville to Louisville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in Knoxville and Louisville?
Frequently asked questions for your trip Knoxville (TN) - Louisville
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville to Louisville was searched and found on May 27, 2025 with a price of $56To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville to Louisville, as early as possible.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Knoxville and Louisville!
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Knoxville to Louisville, get comfy and count the stars.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Knoxville to Louisville that are otherwise impossible to come by with a plane.
Tune out to the fine sounds of your best music playlist on your bus trip from Knoxville to Louisville while indulging in miles on end of beautiful scenic views.
Did you know?
Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
Top traveled bus routes
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The Best Way To Book Bus and Train Tickets
Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. Use Busbud to book your trip online, in your own language and currency, wherever you are. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.
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Popular Buses Connecting Knoxville
Buses Leaving from Knoxville
- Bus from Knoxville to Charlotte
- Bus Knoxville - Marathon
- Knoxville - Orlando
- Bus from Knoxville to Lexington
- Bus Knoxville - New York
- Knoxville - Chicago
- Bus from Knoxville to Nashville
- Bus Knoxville - Atlanta
- Knoxville - Memphis
- Bus from Knoxville to Washington
- Bus Knoxville - Miami
- Knoxville - Jackson
- Bus from Knoxville to Dallas
- Bus Knoxville - Greenville
- Knoxville - Cincinnati
Buses Going to Knoxville
- Bus from Nashville to Knoxville
- Bus Memphis - Knoxville
- Charlotte - Knoxville
- Bus from Chicago to Knoxville
- Bus Tampa - Knoxville
- Richmond - Knoxville
- Bus from Atlanta to Knoxville
- Bus New York - Knoxville
- Greenville - Knoxville
- Bus from Dallas to Knoxville
- Bus Louisville - Knoxville
- Lexington - Knoxville
- Bus from Baltimore to Knoxville
- Bus Washington - Knoxville
- Cincinnati - Knoxville