How much is the bus ticket from Tampa to Knoxville?

The cheapest bus tickets from Tampa to Knoxville start from $100. The average price for this route is around $139. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Tampa to Knoxville?

The average bus trip duration from Tampa to Knoxville is 1d , covering a distance of 554 miles (893 km). The quickest bus can get you there in 22h 45m and is operated by FlixBus .

Which bus companies service the Tampa to Knoxville route?

Several major bus companies operate on this route with 2 buses available per day, including services from Greyhound , FlixBus .

What is the earliest and latest departure time for the bus from Tampa to Knoxville?

The earliest bus departs from Tampa to Knoxville at 2:40pm. And the latest bus departs at 10:35pm.

What are the CO₂ emissions for the bus trip from Tampa to Knoxville?

A bus trip from Tampa to Knoxville generates an estimated 22 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

What is the best bus company from Tampa to Knoxville?

According to Busbud customers, the highest-rated bus company on this route is Greyhound , with an average rating of 3.5 out of 5 stars based on 87387 reviews.

Which bus company has the best Wi-Fi from Tampa to Knoxville?

Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.

Which bus company has the most timely service from Tampa to Knoxville?

According to Busbud traveller reviews, the most timely bus company on this route is FlixBus , with a punctuality rating of 3.9 out of 5 stars.

Which bus company has the cleanest buses from Tampa to Knoxville?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus , with a cleanliness rating of 4.1 out of 5 stars.

Bus Tampa to Knoxville from $100 | Refundable Tickets

Previously seen trips

Next departures for Tampa to Knoxville on November 29
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound	Bus	10:00pm	Tampa Bus Station	1d	10:20pm	Knoxville Bus Station	No tags
Greyhound + FlixBus	Bus	10:00pm	Tampa Bus Station	1d	10:20pm	Knoxville Bus Station	No tags
Greyhound + FlixBus	Bus	4:20pm	Tampa Bus Station	1d 6h	10:40pm	Knoxville Bus Station	No tags
Greyhound + FlixBus	Bus	10:00pm	Tampa Bus Station	1d	10:20pm	Knoxville Bus Station	No tags
	Bus	1:45pm	Tampa Bus Station	1d 8h	10:20pm	Knoxville Bus Station	No tags

Get from Tampa to Knoxville

This route is served by bus only

The journey takes about 1 day and with fares starting at just $100, it presents an excellent value for a comfortable ride.

2bus per day

1d Average Duration

554 milesDistance

22kgCO₂ emissions

Where are the popular stops in Tampa and Knoxville?

Stops in Tampa

A
Tampa 13th Avenue Bus Stop (McDonald's)
2101 E 13th Ave (McDonald's), Tampa, FL 33605
B
Tampa USF, FL
3801 USF Holly Drive, Tampa., FL 33620, USA
C
Greyhound Station
610 E Polk St, Tampa, FL 33602, USA
D
E Sligh Ave
11555 E Sligh Ave, Seffner, FL 33584, USA
E
N Marion St & E Laurel St
551 E Laurel St, Tampa, FL 33602, USA
F
Port of Tampa
200-298 FL-60, Tampa, FL 33602, USA

Stops in Knoxville

A
100 Kirkwood St
Knoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Visit page

Compare bus companies

Greyhound

3.5/587,407 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

Greyhound Tampa Knoxville recent customer reviews

Was when I arrived in Knoxville I got dropped off at a bus stop not bus station

Michael D.

January 2, 2023

FlixBus

3.5/511,472 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

FlixBus Tampa Knoxville recent customer reviews

When I enjoyed was the ride, it was a comfortable ride.What I didnt enjoy was all the long wait times from catching your next bus That was too long.I have to wait 4 hours some 2 hours and 40 minutes.I wish I could have a short Those But overall it was good

Michael D.

July 7, 2025

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about traveling from Tampa to Knoxville, TN by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Tampa to Knoxville?
The cheapest bus tickets from Tampa to Knoxville start from $100. The average price for this route is around $139. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Tampa to Knoxville?
The average bus trip duration from Tampa to Knoxville is 1d , covering a distance of 554 miles (893 km). The quickest bus can get you there in 22h 45m and is operated by FlixBus.
Which bus companies service the Tampa to Knoxville route?
Several major bus companies operate on this route with 2 buses available per day, including services from Greyhound, FlixBus.
What is the earliest and latest departure time for the bus from Tampa to Knoxville?
The earliest bus departs from Tampa to Knoxville at 2:40pm. And the latest bus departs at 10:35pm.
What are the CO₂ emissions for the bus trip from Tampa to Knoxville?
A bus trip from Tampa to Knoxville generates an estimated 22 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Tampa to Knoxville?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87387 reviews.
Which bus company has the best Wi-Fi from Tampa to Knoxville?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Tampa to Knoxville?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Tampa to Knoxville?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.