Next bus departures

Next departures for Rochester to Indianapolis on October 15
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus Wifi Toilet Power outlets	8:50am	Rochester	18h 10m	3:00am	Indianapolis (W Vermont St)	Cheapest
	Bus Wifi Toilet Power outlets	6:10am	Rochester	13h 15m	7:25pm	Indianapolis Bus Station	Fastest
	Bus Wifi Toilet Power outlets	9:15pm	Rochester	19h 30m	4:45pm	Indianapolis Bus Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus Wifi Toilet Power outlets	9:15pm	Rochester	16h	1:15pm	Indianapolis (W Vermont St)	No tags

Last refresh of the prices: Today at 1:10 PM EDT.

Compare 2 ways to go from Rochester to Indianapolis

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as a good way to reach Indianapolis. The journey takes about 16 hours and with fares starting at just COP 254,472, it presents an excellent value for a comfortable ride.

4bus per day

16hAverage Duration

500 milesDistance

20kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average PriceCOP 254,472 - COP 547,853	Average Duration16h	CO₂ emissions 20kg CO₂e
Train	Average PriceCOP 526,447 - COP 1,635,887	Average Duration1d	CO₂ emissions 73kg CO₂e

Bus stations and stops in Rochester and Indianapolis

Stops in Rochester

A
Bus Station
186 Cumberland St (Across from the Amtrak Terminal) , Rochester, NY 14605
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B
U of R
Rush Rhees Library, 755 Library Road, Rochester, NY 14627
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C
Rochester Institute of Technology
61 Lomb Memorial Dr, Rochester, NY 14623
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Stops in Indianapolis

A
Greyhound Amtrak Station
350 S Illinois St, Indianapolis, IN 46225
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Compare bus companies

Greyhound

3.5/588,215 reviews

Staff3.6

Timeliness3.0

Cleanliness3.4

Wifi2.5

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

FlixBus

3.5/516,143 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

US bus companies:FlixBus, Greyhound, Tufesa, Chihuahuenses, Adirondack Trailways, Valley Transit, Wanda Coach

Frequently asked questions about traveling from Rochester, NY, US to Indianapolis by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Rochester to Indianapolis?
The cheapest bus tickets from Rochester to Indianapolis start from COP 254,472. The average price for this route is around COP 362,679. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Rochester to Indianapolis?
The average bus trip duration from Rochester to Indianapolis is 16h, covering a distance of 500 miles (806 km). The quickest bus can get you there in 13h 15m and is operated by Greyhound.
Which bus companies service the Rochester to Indianapolis route?
Several major bus companies operate on this route with 4 buses available per day, including services from Greyhound, FlixBus.
What is the earliest and latest departure time for the bus from Rochester to Indianapolis?
The earliest bus departs from Rochester to Indianapolis at 6:10am. And the latest bus departs at 9:15pm.
What are the CO₂ emissions for the bus trip from Rochester to Indianapolis?
A bus trip from Rochester to Indianapolis generates an estimated 20.1498 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Rochester to Indianapolis?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 88182 reviews.
Which bus company has the best Wi-Fi from Rochester to Indianapolis?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Rochester to Indianapolis?
According to Busbud traveler reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Rochester to Indianapolis?
According to Busbud traveler reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

10/07

COP 276,860

10/08

COP 275,221

Today

COP 327,702

10/10

COP 316,196

10/11

No data

10/12

No data

10/13

No data

10/14

No data

The cheapest trip from Rochester, NY, US to Indianapolis was searched and found on Oct 8, 2026 with a price of COP 275,221

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rochester, NY, US to Indianapolis, as early as possible.

You can expect to pay from COP 275,221 to COP 358,811 for a bus ticket from Rochester, NY, US to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at COP 316,196 which is on 2026-10-10.