Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Rochester | Downtown Transit Center | Cheapest | ||||
 | Bus | Rochester | Indianapolis Bus Station | Fastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Rochester | Indianapolis Bus Station | No tags |
Last refresh of the prices: Yesterday at 2:56 PM EST.
Compare 2 ways to go from Rochester to Indianapolis
Among the sustainable travel choices, the train stands out as the good way to reach Indianapolis. The journey takes about 1 day, 20 minutes and with fares starting at just $130, it presents an excellent value for a comfortable ride.
Where are the popular stops in Rochester and Indianapolis?
Stops in Rochester
- A186 Cumberland St (Across from the Amtrak Terminal) , Rochester, NY 14605
- BRush Rhees Library, 755 Library Road, Rochester, NY 14627
- C
Rochester Institute of Technology
61 Lomb Memorial Dr, Rochester, NY 14623
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Frequently asked questions about traveling from Rochester, NY, US to Indianapolis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Rochester to Indianapolis?
The cheapest bus tickets from Rochester to Indianapolis start from $118. The average price for this route is around $181. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Rochester to Indianapolis?
The average bus trip duration from Rochester to Indianapolis is 1d 3h, covering a distance of 500 miles (806 km). The quickest bus can get you there in 23h 45m and is operated by Greyhound.
Which bus companies service the Rochester to Indianapolis route?
What is the earliest and latest departure time for the bus from Rochester to Indianapolis?
The earliest bus departs from Rochester to Indianapolis at 12:35am. And the latest bus departs at 11:35pm.
What are the CO₂ emissions for the bus trip from Rochester to Indianapolis?
A bus trip from Rochester to Indianapolis generates an estimated 20 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Rochester to Indianapolis?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87412 reviews.
Which bus company has the best Wi-Fi from Rochester to Indianapolis?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Rochester to Indianapolis?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Rochester to Indianapolis?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Rochester, NY, US to Indianapolis was searched and found on Dec 18, 2025 with a price of $123To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rochester, NY, US to Indianapolis, as early as possible.
You can expect to pay from $123 to $186 for a bus ticket from Rochester, NY, US to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $123 which is on 2025-12-18.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
