Bus New Orleans to Knoxville, TN: Trip Overview
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Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
New Orleans to Knoxville Bus
Busbud helps you find a bus from New Orleans to Knoxville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
We make sure you can find a bus service from New Orleans to Knoxville from the most reliable bus companies operating this trip.
Whether it is cheap bus tickets or more luxurious buses going to Knoxville from New Orleans, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in New Orleans and Knoxville?
Frequently asked questions for your trip New Orleans - Knoxville, TN
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from New Orleans to Knoxville, TN was searched and found on Jul 25, 2025 with a price of $114To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from New Orleans to Knoxville, TN, as early as possible.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between New Orleans and Knoxville!
Start sightseeing the minute your bus leaves the station. If you're on the night bus from New Orleans to Knoxville, get comfy and count the stars.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from New Orleans to Knoxville.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from New Orleans to Knoxville.
Did you know?
Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
Top traveled bus routes
Why choose Busbud?
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Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.
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Continue your journey from Knoxville
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