Bus Tickets from St. Louis to Santa Ana, US

Previously seen trips

Next departures for St. Louis to Santa Ana on September 21
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound
Gateway Station
Santa Ana Bus StationNo tags
Greyhound
Gateway Station
Santa Ana Bus StationNo tags
Greyhound
Saint Louis (Lambert Field)
Santa Ana Bus StationNo tags
FlixBus + Greyhound
Saint Louis (Lambert Field)
UC Irvine (Crawford Hall)No tags
Greyhound + FlixBus
Saint Louis (Lambert Field)
Santa Ana Bus StationNo tags

Accepted payments

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Bus St. Louis to Santa Ana, US: Trip Overview

Average ticket price$162
Average bus trip duration2d 2h
Number of daily buses8
Earliest bus departure1:15am
Distance1569 miles (2530 km)
Latest bus departure4:30pm

St. Louis to Santa Ana Bus

With Busbud, comparing and booking tickets for a bus from St. Louis to Santa Ana is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from St. Louis to Santa Ana will be provided by the most trusted bus companies.

Whether it is cheap bus tickets or more luxurious buses going to Santa Ana from St. Louis, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip St. Louis - Santa Ana, US

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09/18
No data
09/19
No data
Today
No data
09/21
No data
09/22
$146
09/23
No data
09/24
No data
09/25
$153
busbud logoThe cheapest trip from St. Louis to Santa Ana, US was searched and found on Sep 22, 2025 with a price of $146

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Santa Ana, US, as early as possible.

You can expect to pay from $146 to $153 for a bus ticket from St. Louis to Santa Ana, US based on the last 2 days. You can expect to find the cheapest price for the trip at $146 which is on 2025-09-22.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from St. Louis to Santa Ana.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from St. Louis to Santa Ana, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St. Louis to Santa Ana.

Tune out to the fine sounds of your best music playlist on your bus trip from St. Louis to Santa Ana while indulging in miles on end of beautiful scenic views.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Will you be returning to St. Louis by bus?

Bus from Santa Ana, US to St. Louis

Why choose Busbud?

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Popular Buses Connecting Santa Ana

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