How can I travel from Tampa to Greenville without flying?

You can take a bus or a train to go from Tampa to Greenville. Either way you choose, you'll be sure to reach your destination in the most practical and sustainable way. Another option is using carpool services and riding with fellow travelers.

How long does it take to get to Greenville from Tampa by bus?

On average, the trip from Tampa to Greenville takes around 15h 35m, although the minimum time it takes to get there is 13h 15m with the fastest bus. This is the time it takes to travel the 477 miles (769 km) that separate the two cities.

What is the travel distance from Tampa to Greenville?

The distance separating Tampa and Greenville is 477 miles (769 km).

What are the departure and arrival stations when taking the bus from Tampa to Greenville?

The majority of buses traveling from Tampa to Greenville start their journey at Tampa 13th Avenue Bus Stop (McDonald's) and wind up at Guadalajara Supermarket Bus Stop. These are the main pick-up and drop-off locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.

What is the most cost-effective way to go from Tampa to Greenville?

You can save a lot of money on your trip from Tampa to Greenville by choosing to travel by bus. $75 is the starting point for the cost-effective bus ride to Greenville from Tampa.

How much are the bus tickets from Tampa to Greenville?

You can expect to pay around $112 for a bus ticket. Over the last 30 days, the prices ranged between $75 and $186, so make sure to compare them to get the best option.

Is there an overnight bus from Tampa to Greenville?

Yes, you can take a night bus to go from Tampa to Greenville. Don't forget to bring a snack and a blanket to help you stay comfortable through the night.

Tampa to Greenville (SC) Bus Tickets

TodayMay 22

from $98

TomorrowMay 23

SatMay 24

SunMay 25

MonMay 26

TueMay 27

WedMay 28

ThuMay 29

Next departures to Greenville

One passenger / one way

This trip is recommended because it is: Cheapest
Departure time: May 22 at 10:35pm
Departure city: Tampa
Departure location: Tampa Bus Station
Arrival time: May 23 at 8:25pm
Destination city: Greenville
Destination location: 1116 Woodruff Rd
Operated by: FlixBus + Greyhound Lines, Inc.
FlixBus + Greyhound Lines, Inc.
Vehicle: BusDuration: 21h 50m
This trip is recommended because it is: Fastest
Departure time: May 22 at 5:40pm
Departure city: Tampa
Departure location: University of South Florida
Arrival time: May 23 at 7:35am
Destination city: Greenville
Destination location: 1116 Woodruff Rd
Operated by: FlixBus + Greyhound Lines, Inc.
FlixBus + Greyhound Lines, Inc.
Vehicle: BusDuration: 13h 55m
Departure time: May 22 at 10:25am
Departure city: Tampa
Departure location: Union Station
Arrival time: May 24 at 5:24am
Destination city: Greenville
Destination location: Greenville Station
Operated by: Amtrak
Vehicle: BusDuration: 1d 18h
Departure time: May 22 at 5:10pm
Departure city: Tampa
Departure location: Tampa Bus Station
Arrival time: May 23 at 7:35am
Destination city: Greenville
Destination location: 1116 Woodruff Rd
Operated by: FlixBus + Greyhound Lines, Inc.
FlixBus + Greyhound Lines, Inc.
Vehicle: BusDuration: 14h 25m
Departure time: May 22 at 10:25am
Departure city: Tampa
Departure location: Union Station
Arrival time: May 24 at 5:24am
Destination city: Greenville
Destination location: Greenville Station
Operated by: Amtrak
Vehicle: BusDuration: 1d 18h

Accepted payments

Compare 2 ways to go from Tampa to Greenville.

	Average Price	Average Duration	CO₂ emissions
Bus	Average Price$75 - $186	Average Duration15h 35m	CO₂ emissions 19kg CO₂e5 out of 5 stars	CheapestFastestMost eco-friendly
Train	Average Price$341 - $341	Average Duration1d 12h	CO₂ emissions 70kg CO₂e1 out of 5 stars

Busbud recommends taking the bus from Tampa to Greenville

Among the sustainable travel choices, the bus stands out as the good way to reach Greenville. The journey takes about 15 hours 35 minutes and with fares starting at just $75, it presents an excellent value for a comfortable ride.

4bus per day

15h 35mAverage Duration

$75Cheapest ticket

19kgCO₂ emissions

Bus Tampa to Greenville: Trip Overview

Average ticket price$112

Average bus trip duration15h 35m

Number of daily buses4

Earliest bus departure6:20am

Distance467 miles (752 km)

Latest bus departure10:35pm

Compare bus companies

FlixBus

3.5/58,709 reviews

Staff4.1

Timeliness4

Cleanliness4.1

Wifi2.6

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

Greyhound

3.5/586,994 reviews

Staff3.6

Timeliness2.8

Cleanliness3.3

Wifi2.3

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

Amtrak

4/55,134 reviews

Staff4.7

Timeliness3.8

Cleanliness4.6

Wifi3.6

US bus companies: FlixBus, Greyhound, Los Limousines, Tornado Bus, Valley Transit, Tufesa, Wanda Coach

Tampa to Greenville Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Tampa to Greenville.

Bus service from Tampa to Greenville will be provided by the most trusted bus companies.

Whether it is cheap bus tickets or more luxurious buses going to Greenville from Tampa, we help you find what you're looking for based on how much of a budget you have.

Where are the popular stops in Tampa and Greenville?

Stops in Tampa

A - Tampa 13th Avenue Bus Stop (McDonald's)

B - Tampa USF, FL

C - Greyhound Station

D - E Sligh Ave

E - N Marion St & E Laurel St

F - Port of Tampa

Stops in Greenville

A - Guadalajara Supermarket Bus Stop

B - Greenville Bus Station

Frequently asked questions for your trip Tampa - Greenville (SC)

How can I travel from Tampa to Greenville without flying?
How long does it take to get to Greenville from Tampa by bus?
What is the travel distance from Tampa to Greenville?
What are the departure and arrival stations when taking the bus from Tampa to Greenville?
What is the most cost-effective way to go from Tampa to Greenville?
How much are the bus tickets from Tampa to Greenville?
Is there an overnight bus from Tampa to Greenville?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

05/20

$573

05/21

No data

Today

$427

05/23

No data

05/24

$90

05/25

No data

05/26

No data

05/27

No data

The cheapest trip from Tampa to Greenville was searched and found on May 24, 2025 with a price of $90

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tampa to Greenville, as early as possible.

You can expect to pay from $90 to $1,911 for a bus ticket from Tampa to Greenville based on the last 2 days. You can expect to find the cheapest price for the trip at $90 which is on 2025-05-24.

Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Tampa to Greenville but it'll also be endearing to native speakers who will surely appreciate your effort.

Much more than a mere vehicle taking you from Tampa to Greenville, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Tampa to Greenville.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Tampa to Greenville.

Did you know?

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

What's the cheapest way to go from Tampa to Greenville?

The bus is the cheapest travel choice for this destination

Vehicle Type	Travel Time	Avg Price	Daily Departures
Vehicle TypeBus	Travel Time15h 35m	Avg Price$112	Daily Departures4
Vehicle TypeTrain	Travel Time1d 12h	Avg Price$341	Daily Departures1

Will you be returning to Tampa by bus?

Bus from Tampa to Greenville

You can also go to Greenville by train

Train from Tampa to Greenville

Top traveled bus routes

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

Bus Tickets from Tampa to Greenville (SC)

Next departures to Greenville

One passenger / one way

Compare 2 ways to go from Tampa to Greenville.

Bus Tampa to Greenville: Trip Overview

Compare bus companies

Tampa to Greenville Bus

Where are the popular stops in Tampa and Greenville?

Frequently asked questions for your trip Tampa - Greenville (SC)

How can I travel from Tampa to Greenville without flying?

How long does it take to get to Greenville from Tampa by bus?

What is the travel distance from Tampa to Greenville?

What are the departure and arrival stations when taking the bus from Tampa to Greenville?

What is the most cost-effective way to go from Tampa to Greenville?

How much are the bus tickets from Tampa to Greenville?

Is there an overnight bus from Tampa to Greenville?

Find cheapest prices for buses

About Bus Travel

Bus Travel Tips

Did you know?

What's the cheapest way to go from Tampa to Greenville?

Will you be returning to Tampa by bus?

You can also go to Greenville by train

Top traveled bus routes

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

People from around the world trust Busbud

Popular Buses Connecting Tampa

Buses Leaving from Tampa

Buses Going to Tampa

Popular Buses Connecting Greenville

Buses Leaving from Greenville

Buses Going to Greenville

Popular routes in this country

Popular airport transfers