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- This trip is recommended because it is: Cheapest + FastestDeparture time: August 4 atDeparture city: St. LouisDeparture location: Gateway StationArrival time: August 6 atDestination city: San FranciscoDestination location: San Francisco Bus StationOperated by: Greyhound Lines, Inc.
Vehicle: BusDuration: - Departure time: August 4 atDeparture city: St. LouisDeparture location: Gateway StationArrival time: August 6 atDestination city: San FranciscoDestination location: San Francisco Bus StationOperated by: Greyhound Lines, Inc.Vehicle: BusDuration:
- Departure time: August 4 atDeparture city: St. LouisDeparture location: Saint Louis (Lambert Field)Arrival time: August 6 atDestination city: San FranciscoDestination location: San Francisco Bus StationOperated by: Greyhound Lines, Inc.Vehicle: BusDuration:
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Compare 2 ways to go from St. Louis to San Francisco.
Busbud recommends taking the bus from St. Louis to San FranciscoAmong the sustainable travel choices, the bus stands out as the good way to reach San Francisco. The journey takes about 2 days, 1 hour 10 minutes and with fares starting at just $144, it presents an excellent value for a comfortable ride.
Bus St. Louis to San Francisco, US: Trip Overview
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Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
St. Louis to San Francisco Bus
With Busbud, comparing and booking tickets for a bus from St. Louis to San Francisco is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
We make sure you can find a bus service from St. Louis to San Francisco from the most reliable bus companies operating this trip.
From cheap bus tickets to more luxurious buses traveling from St. Louis to San Francisco, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in St. Louis and San Francisco?
Frequently asked questions for your trip St. Louis - San Francisco, US
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from St. Louis to San Francisco, US was searched and found on Aug 4, 2025 with a price of $196To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to San Francisco, US, as early as possible.
You can expect to pay from $196 to $258 for a bus ticket from St. Louis to San Francisco, US based on the last 2 days. You can expect to find the cheapest price for the trip at $196 which is on 2025-08-04.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while traveling from St. Louis to San Francisco.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from St. Louis to San Francisco, get comfy and count the stars.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from St. Louis to San Francisco that are otherwise impossible to come by with a plane.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from St. Louis to San Francisco.
Did you know?
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
What's the cheapest way to go from St. Louis to San Francisco, US?
The bus is the cheapest travel choice for this destinationTop traveled bus routes
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Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.
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