Bus Tickets from St. Louis to San Francisco, US

Next departures

Next departures for St. Louis to San Francisco on October 15
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc. + FlixBus
Gateway Station
409 Townsend St, SFCheapest
Greyhound Lines, Inc.
Gateway Station
San Francisco Bus StationFastest
Greyhound Lines, Inc.
Gateway Station
San Francisco Bus StationNo tags

Last refresh of the prices: Yesterday at 6:56 PM CDT.

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Bus St. Louis to San Francisco, US: Trip Overview

Average ticket price$235
Average bus trip duration2d 1h
Number of daily buses6
Earliest bus departure1:20am
Distance1736 miles (2800 km)
Latest bus departure4:30pm

St. Louis to San Francisco Bus

With Busbud, comparing and booking tickets for a bus from St. Louis to San Francisco is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from St. Louis to San Francisco from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses traveling from St. Louis to San Francisco, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip St. Louis - San Francisco, US

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10/12
No data
10/13
No data
Today
$260
10/15
$327
10/16
$243
10/17
$276
10/18
$202
10/19
No data
busbud logoThe cheapest trip from St. Louis to San Francisco, US was searched and found on Oct 18, 2025 with a price of $202

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to San Francisco, US, as early as possible.

You can expect to pay from $202 to $481 for a bus ticket from St. Louis to San Francisco, US based on the last 2 days. You can expect to find the cheapest price for the trip at $202 which is on 2025-10-18.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from St. Louis to San Francisco.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from St. Louis to San Francisco, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from St. Louis to San Francisco that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from St. Louis to San Francisco.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Will you be returning to St. Louis by bus?

Bus from San Francisco, US to St. Louis

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