Bus Tickets from St Louis, MO to San Diego, CA

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ThuMay 15
FriMay 16
from $146
SatMay 17
SunMay 18
MonMay 19
TueMay 20
WedMay 21
ThuMay 22

Cheap buses leaving Friday

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: May 16 at
    Departure city: St Louis
    Departure location: St Louis, MO
    Arrival time: May 19 at
    Destination city: San Diego
    Destination location: Balboa Park
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: May 16 at
    Departure city: St Louis
    Departure location: Gateway Station
    Arrival time: May 17 at
    Destination city: San Diego
    Destination location: UCSD Health La Jolla Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: May 16 at
    Departure city: St Louis
    Departure location: Gateway Station
    Arrival time: May 17 at
    Destination city: San Diego
    Destination location: San Diego (Old Town-FlixBus)
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: May 16 at
    Departure city: St Louis
    Departure location: Gateway Station
    Arrival time: May 17 at
    Destination city: San Diego
    Destination location: Greyhound Bus Stop
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: May 16 at
    Departure city: St Louis
    Departure location: Gateway Station
    Arrival time: May 18 at
    Destination city: San Diego
    Destination location: San Diego (Old Town-FlixBus)
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:

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Compare 2 ways to go from St Louis to San Diego.

Bus
Average Price$94 - $444Average Duration2d 3h
63kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average Price$219 - $389Average Duration2d 8h
229kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from St Louis to San Diego

Among the sustainable travel choices, the bus stands out as the good way to reach San Diego. The journey takes about 2 days, 3 hours 20 minutes and with fares starting at just $94, it presents an excellent value for a comfortable ride.

14bus per day
2d 3hAverage Duration
$94Cheapest ticket
63kgCO₂ emissions

Bus St Louis to San Diego: Trip Overview

Average ticket price$204
Average bus trip duration2d 3h
Number of daily buses14
Earliest bus departure1:35am
Distance1557 miles (2510 km)
Latest bus departure7:00pm

St Louis to San Diego Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from St Louis to San Diego.

We make sure you can find a bus service from St Louis to San Diego from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to San Diego from St Louis, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip St Louis - San Diego

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05/11
$298
05/12
No data
Today
No data
05/14
No data
05/15
No data
05/16
$178
05/17
No data
05/18
No data
busbud logoThe cheapest trip from St Louis to San Diego was searched and found on May 16, 2025 with a price of $178

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St Louis to San Diego, as early as possible.

You can expect to pay from $178 to $451 for a bus ticket from St Louis to San Diego based on the last 2 days. You can expect to find the cheapest price for the trip at $178 which is on 2025-05-16.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from St Louis to San Diego but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from St Louis to San Diego, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St Louis to San Diego.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from St Louis to San Diego.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

What's the cheapest way to go from St Louis to San Diego?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to St Louis by bus?

Bus from St Louis to San Diego

You can also go to San Diego by train

Train from St Louis to San Diego

Why choose Busbud?

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