Bus Tickets from Syracuse, US to St. Louis

Next departures

Next departures for Syracuse to St. Louis on October 31
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.
Syracuse (Regional Transportation Center)
Gateway StationCheapestFastest
Greyhound Lines, Inc.
Syracuse (Regional Transportation Center)
Gateway StationNo tags
Greyhound Lines, Inc.
Syracuse (Regional Transportation Center)
Gateway StationNo tags

Last refresh of the prices: Today at 3:01 PM EDT.

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Compare 2 ways to go from Syracuse to St. Louis

busbud logoWe recommend taking the train

Among the sustainable travel choices, the train stands out as the good way to reach St. Louis. The journey takes about 22 hours 2 minutes and with fares starting at just $189, it presents an excellent value for a comfortable ride.

1train per day
22h 2mAverage Duration
793 milesDistance
116kgCO₂ emissions
Bus
Average Price$110 - $357Average Duration1d 3h
32kg CO₂e
Train
Average Price$189 - $1,102Average Duration22h 2m
116kg CO₂e

Bus Syracuse, US to St. Louis: Trip Overview

Average ticket price$165
Average bus trip duration1d 3h
Number of daily buses3
Earliest bus departure4:30am
Distance793 miles (1278 km)
Latest bus departure9:00pm

Syracuse to St. Louis Bus

With Busbud, comparing and booking tickets for a bus from Syracuse to St. Louis is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Syracuse to St. Louis from the most reliable bus companies operating this trip.

Discover how much the bus trip from Syracuse to St. Louis will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip Syracuse, US - St. Louis

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10/28
No data
10/29
No data
Today
$148
10/31
$193
11/01
No data
11/02
No data
11/03
No data
11/04
No data
busbud logoThe cheapest trip from Syracuse, US to St. Louis was searched and found on Oct 30, 2025 with a price of $148

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to St. Louis, as early as possible.

You can expect to pay from $148 to $263 for a bus ticket from Syracuse, US to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $193 which is on 2025-10-31.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Syracuse to St. Louis.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Syracuse to St. Louis, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Syracuse to St. Louis will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from Syracuse to St. Louis, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

What's the cheapest way to go from Syracuse, US to St. Louis?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Syracuse, US by bus?

Bus from St. Louis to Syracuse, US

You can also go to St. Louis by train

Train from Syracuse, US to St. Louis

Why choose Busbud?

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